rhBMP-2 linked to increased rate of retrograde ejaculation

rhBMP-2 linked to increased rate of retrograde ejaculation
For patients with lumbar spondylosis or spondylolisthesis of the lowest lumbar levels who undergo open anterior lumbar interbody fusion, use of recombinant human bone morphogenetic protein-2 is associated with an increased rate of retrograde ejaculation, according to research published in the October issue of The Spine Journal.

(HealthDay)—For patients with lumbar spondylosis or spondylolisthesis of the lowest lumbar levels who undergo open anterior lumbar interbody fusion (ALIF), use of recombinant human bone morphogenetic protein-2 (rhBMP-2) is associated with an increased rate of retrograde ejaculation (RE), according to research published in the October issue of The Spine Journal.

Garet C. Comer, M.D., from Stanford University in Redwood City, Calif., and colleagues retrospectively analyzed 10 years of prospectively gathered outcomes data from four consecutive-patient cohorts of males who underwent the same anterior exposure technique for ALIF for lumbar spondylosis or at the lowest one or two levels. Two cohorts had rhBMP-2 exposure (88 and 151 men) and the other two had no exposure (one before adoption of rhBMP-2 use, 174 men; one after discontinuation of rhBMP-2, 59 men).

The researchers identified a diagnosis of RE in 6.3 percent of 239 patients with ALIF and exposure to rh-BMP-2 and in 0.9 percent of 233 control patients without rhBMP-2 exposure. In patients exposed to rhBMP-2, urinary retention after bladder catheter removal was observed more frequently (9.7 percent) compared with control patients (4.6 percent; P = 0.043). Medical or surgical treatment for prostatic hypertrophy disease was significantly associated with an increased risk of RE in the rhBMP-2 treated patients (P = 0.034).

"This study supports multiple lines of evidence that strongly suggest rhBMP-2 use with an anterior interbody fusion at the lumbosacral junction is associated with an increased risk of RE," the authors write.

Several authors disclosed to the medical device industry.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Instrumented spinal fusion method impacts infection rate

May 21, 2012

(HealthDay) -- For patients who undergo instrumented spinal fusion, the rates of infection are higher among those who receive posterior lumbar interbody fusion compared with those who receive posterior or ...

Spondylolisthesis linked to spinous process fractures

Jun 02, 2012

(HealthDay) -- There is a strong association between degenerative spondylolisthesis and spinous process fracture in patients undergoing interspinous process spacer (IPS) surgery, according to a study published ...

Oxiplex improves outcomes after lumbar discectomy

Apr 24, 2012

(HealthDay) -- The use of Oxiplex gel (containing carboxymethylcellulose, polyethylene oxide, and calcium) to coat the surgical site during discectomy procedures for the treatment of lumbar disc herniation ...

Recommended for you

Evidence-based recs issued for systemic care in psoriasis

9 hours ago

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

9 hours ago

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

9 hours ago

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

Discovery of genes that predispose a severe form of COPD

12 hours ago

A study by Ramcés Falfán-Valencia, researcher at the National Institute of Respiratory Diseases (INER), found that the mestizo Mexican population has a number of variations in certain genes that predispose ...

On the environmental trail of food pathogens

13 hours ago

Tracking one of the deadliest food contamination organisms through produce farms and natural environments alike, Cornell microbiologists are showing how to use big datasets to predict where the next outbreak could start.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.