rhBMP-2 linked to increased rate of retrograde ejaculation

rhBMP-2 linked to increased rate of retrograde ejaculation
For patients with lumbar spondylosis or spondylolisthesis of the lowest lumbar levels who undergo open anterior lumbar interbody fusion, use of recombinant human bone morphogenetic protein-2 is associated with an increased rate of retrograde ejaculation, according to research published in the October issue of The Spine Journal.

(HealthDay)—For patients with lumbar spondylosis or spondylolisthesis of the lowest lumbar levels who undergo open anterior lumbar interbody fusion (ALIF), use of recombinant human bone morphogenetic protein-2 (rhBMP-2) is associated with an increased rate of retrograde ejaculation (RE), according to research published in the October issue of The Spine Journal.

Garet C. Comer, M.D., from Stanford University in Redwood City, Calif., and colleagues retrospectively analyzed 10 years of prospectively gathered outcomes data from four consecutive-patient cohorts of males who underwent the same anterior exposure technique for ALIF for lumbar spondylosis or at the lowest one or two levels. Two cohorts had rhBMP-2 exposure (88 and 151 men) and the other two had no exposure (one before adoption of rhBMP-2 use, 174 men; one after discontinuation of rhBMP-2, 59 men).

The researchers identified a diagnosis of RE in 6.3 percent of 239 patients with ALIF and exposure to rh-BMP-2 and in 0.9 percent of 233 control patients without rhBMP-2 exposure. In patients exposed to rhBMP-2, urinary retention after bladder catheter removal was observed more frequently (9.7 percent) compared with control patients (4.6 percent; P = 0.043). Medical or surgical treatment for prostatic hypertrophy disease was significantly associated with an increased risk of RE in the rhBMP-2 treated patients (P = 0.034).

"This study supports multiple lines of evidence that strongly suggest rhBMP-2 use with an anterior interbody fusion at the lumbosacral junction is associated with an increased risk of RE," the authors write.

Several authors disclosed to the medical device industry.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Instrumented spinal fusion method impacts infection rate

date May 21, 2012

(HealthDay) -- For patients who undergo instrumented spinal fusion, the rates of infection are higher among those who receive posterior lumbar interbody fusion compared with those who receive posterior or ...

Spondylolisthesis linked to spinous process fractures

date Jun 02, 2012

(HealthDay) -- There is a strong association between degenerative spondylolisthesis and spinous process fracture in patients undergoing interspinous process spacer (IPS) surgery, according to a study published ...

Oxiplex improves outcomes after lumbar discectomy

date Apr 24, 2012

(HealthDay) -- The use of Oxiplex gel (containing carboxymethylcellulose, polyethylene oxide, and calcium) to coat the surgical site during discectomy procedures for the treatment of lumbar disc herniation ...

Recommended for you

UK nurse cured of Ebola after receiving new treatment

date 2 hours ago

A British army reservist who contracted Ebola while working as a volunteer nurse in Sierra Leone has fully recovered after becoming the first patient in the world to receive an experimental new treatment.

COPD takes big toll on employment, mobility in US

date 2 hours ago

(HealthDay)—The respiratory illness known as COPD takes a toll on mobility and employment, with a new report finding that nearly one-quarter of Americans with the condition are unable to work.

Genetic test for inherited kidney diseases developed

date 5 hours ago

Many kidney disorders are difficult to diagnose. To address this problem, scientists and clinicians have developed a diagnostic test that identifies genetic changes linked to inherited kidney disorders. This ...

Diagnosing infectious diseases at the point-of-care

date 5 hours ago

A major problem with current testing for infectious diseases in Africa is that it focuses on individual diseases and cannot reliably discriminate between them. Since most infectious diseases have the same ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.