Brain activity linked to TNF inhibitor response in RA

Brain activity linked to TNF inhibitor response in RA
Patients with rheumatoid arthritis who respond to tumor necrosis factor inhibitors show changes in activity in pain-related areas of the brain before clinical signs of improvement are observed, according to a study published in the February issue of Arthritis & Rheumatism.

(HealthDay)—Patients with rheumatoid arthritis who respond to tumor necrosis factor inhibitors (TNFi) show changes in activity in pain-related areas of the brain before clinical signs of improvement are observed, according to a study published in the February issue of Arthritis & Rheumatism.

Juergen Rech, M.D., from the University of Erlangen-Nuremberg in Germany, and colleagues performed functional magnetic resonance imaging (MRI) of the and anatomic MRI of the hand in 10 patients with active rheumatoid before and up to 28 days after starting treatment with TNFi.

The researchers found that patients who responded to TNFi had a greater mean decrease in Disease Activity Score in 28 joints 28 days after starting treatment. Responders had greater activation of the thalamic, limbic, and associative areas of the brain, which decreased within three days of starting treatment. This was followed by clinical responses after seven days and responses on the hand MRI 28 days after starting treatment.

"These data suggest that response to TNFi depends on brain activity in patients, reflecting the subjective perception of disease," Rech and colleagues conclude.

One author disclosed receiving speaking fees from several pharmaceutical companies.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Bring the feet when diagnosing, treating rheumatoid arthritis

Dec 07, 2011

When diagnosing and treating patients with rheumatoid arthritis (RA), clinical research focuses primarily on the joints in the upper body. However, research carried out by rheumatologist Hetty Baan at the University of Twente ...

Data suggest smoking doesn't impact RA treatment response

Dec 21, 2012

(HealthDay)—For patients with early rheumatoid arthritis (RA), smoking status does not impact treatment response to early combination therapy or initial methotrexate treatment with step-up therapy, according ...

Recommended for you

Osteoarthritis patients will benefit from jumping exercise

Feb 18, 2015

Progressive high-impact training improved the patellar cartilage quality of the postmenopausal women who may be at risk of osteoporosis (bone loss) as well as at risk of osteoarthritis. This was found out in the study carry ...

Use of nondrug, nonsurgical options low in hip, knee OA

Feb 16, 2015

(HealthDay)—Usage of nondrug, nonoperative interventions in community-dwelling individuals with hip and knee osteoarthritis (OA) is low, according to research published in the February issue of Arthritis Ca ...

Prevalence of fibromyalgia varies with criteria applied

Feb 13, 2015

(HealthDay)—The prevalence of fibromyalgia varies with the different sets of the American College of Rheumatology (ACR) classification criteria, according to a study published in the February issue of Arthritis & ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.