Experimental drug may work against hepatitis C

March 27, 2013 by Maureen Salamon, Healthday Reporter
Experimental drug may work against hepatitis C
Miravirsen greatly reduced virus in patients in small study.

(HealthDay)—An experimental therapy for hepatitis C—a "silent killer" linked to liver cancer and cirrhosis—has shown promise in tamping down virus levels in early trials.

Experts caution, however, that it's too soon to know if the injectable drug will someday gain a standing among emerging oral medications against the disease.

New research suggests that the drug, miravirsen, could potentially be part of a drug "cocktail" that manages the in much the same way as similar combinations have transformed HIV/AIDS from a death sentence into a chronic, manageable condition.

Miravirsen suppresses molecules the hepatitis C virus needs to reproduce. The drug decreased by about 500-fold at the highest doses used in a small, phase 2 study by an international group of researchers. , a common problem with other hepatitis C medications, did not develop among patients taking miravirsen.

A phase 2 trial evaluates a drug's effectiveness while continuing to assess its safety.

"This is the first real clinical study of this approach and the results are encouraging," said Dr. Judy Lieberman, chairwoman of cellular and molecular medicine at Boston Children's Hospital. "What's exciting to me is that there doesn't seem to be any drug resistance developing. If there's a way to develop a that doesn't require a half a year of treatment ... that would be really exciting, but it's too early to tell."

Lieberman was not involved in the research but co-wrote an editorial accompanying the new study in the March 27 issue of the New England Journal of Medicine.

Hepatitis C is one form of and affects about 170 million people worldwide, according to study background information. It's transmitted by shared needles or, less frequently, through sex. Often symptomless, the infection is a major cause of liver cancer and cirrhosis, or scarring of the liver.

Led by Dr. Harry Janssen, a professor of medicine at the University of Toronto and Erasmus University Rotterdam in the Netherlands, researchers split 36 patients with hepatitis C into four groups. Nine patients in each of the first three groups received a dose of either 3 milligrams (mg), 5 mg or 7 mg of miravirsen per kilogram of body weight for 29 days, while the last nine patients received a placebo. All were followed for 18 weeks.

The so-called viral load of patients receiving the highest dose decreased by about 500-fold, Lieberman said, and the hepatitis C virus was below detectable levels in four of nine patients. Meanwhile, the treatment caused no significant toxic effects in any patients, aside from mild injection-site reactions and a brief increase in liver enzyme levels.

Calling the study "interesting," Dr. David Bernstein, chief of the division of hepatology at North Shore University Hospital in Manhasset, N.Y., said that as an , miravirsen would be less desirable among patients than other new drugs for that can be taken orally.

"It's a novel concept, but it's only 36 patients and a phase 2 study," Bernstein said. "It's impressive that their viral loads came down, but most suffered a recurrence of the virus."

More information: The U.S. Centers for Disease Control and Prevention has more about hepatitis C.

Related Stories

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

Osiris1
1 / 5 (1) Mar 28, 2013
point is the proven decrease of viral load under treatment AND the non-appearance of apparent resistance to the drug so far. like the article claims, this could be part of a 'team concept' approach to manageability treatment regimes.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.