Similar neuro outcomes in preterm infants with low-grade brain bleeding as infants with no bleeding
A new study from researchers at UH Rainbow Babies and Children's Hospital and other centers suggests that preterm infants with a low-grade bleeding in the brain may have similar neurodevelopmental outcomes as infants with no bleeding. The study appears online at JAMA Pediatrics.
The study's lead author Allison Payne, MD MS, a neonatologist at UH Rainbow Babies and Children's Hospital and instructor at Case Western Reserve University School of Medicine, said, "The results are important because it is a large multi-center study showing different results than a recent study that did find differences in outcomes at 2 years of age for babies with PIVH. Our study's results are similar to those reported by other international cohorts."
The bleeding is called periventricular-intraventricular hemorrhage (PIVH), a condition that can occur in preterm babies. Dr. Payne and her colleagues said that although the presence of severe PIVH strongly correlates with adverse motor and cognitive outcomes, "outcomes of survivors with low-grade PIVH (grade 1 or 2) are less fully understood despite accounting for 50 percent to 80 percent of all PIVH cases."
In this study, the researchers analyzed 1472 extremely preterm infants admitted to 16 pediatric medical centers, including UH Rainbow Babies and Children's Hospital, from 2006 to 2008 who survived to 18-22 months and had at least one cranial ultrasonography performed during their stay.
In total, 451 infants were diagnosed with PIVH, of which 31 percent were classified as having grade 1 PIVH, 29 percent as having grade 2, and 40 percent as having grade 3 or 4. Infants with grade 1 or 2 PIVH did not have an increased incidence of poor neurodevelopmental outcomes at 18-22 months compared with infants without PIVH, even after multivariate analysis controlling for potential confounders, including the use of antenatal and postnatal steroids.
Compared with low-grade hemorrhage, severe (grade 3 or 4) hemorrhage was significantly associated with cognitive deficits and language delay, as well as an increased risk for poor nonsensory outcomes (including cerebral palsy) apart from mild language impairment and severe cognitive impairment.
The researchers caution that high-prevalence, low-severity disabilities, such as attention deficit/hyperactivity disorders, specific neuropsychological deficits, and behavioral problems may gradually emerge over the years. "It is not clear what contribution low-grade PIVH may have to these more subtle disabilities," said Dr. Payne. She plans to continue to study these children when they reach school age.
More information: JAMA Pediatr. 2013;():1-9. doi:10.1001/jamapediatrics.2013.866 , http://archpedi.jamanetwork.com/article.aspx?articleid=1659617
Journal reference: JAMA Pediatrics
Provided by University Hospitals Case Medical Center
- Surviving premature babies in Malawi continue to have poor growth rates and development delay Nov 08, 2011 | not rated yet | 0
- Screening very preterm infants for autism at 18 months often inaccurate May 01, 2011 | not rated yet | 0
- More babies survive premature birth, but serious health problems unchanged Dec 04, 2012 | not rated yet | 0
- New research finds slower growth of preterm infants linked to altered brain development Jan 16, 2013 | not rated yet | 0
- Survival rates for premature babies in high-level NICUs are better than previously reported Jul 23, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Basic physics understanding. Could someone explain?
2 hours ago I'm trying to get a grip on some classic physics by watching a Stanford lecture. I've made it through the first one, and now in the second one all...
Change in flux of a transformer
2 hours ago Hello, As I understand, a simple transformer works by using the Input AC in the primary coil to generate magnetic field in the iron core, which...
Electric field between parallel plate capacitor
3 hours ago If you have an infinite non-conducting plate, the electric field just outside is equal to sigma / 2*epsilon. The electric field just outside a...
Why angle of projectile has 2 solutions?
4 hours ago I have the final answer of: sin2(theta) = 0.871 why does (theta) = 30.3 deg OR (theta) = 59.7 deg I get why this could be physically, but...
How much negative charge do I accumulate by touching the earth?
5 hours ago The Earth carries a negative electric charge of roughly 500 thousand Coulombs (according to different sources I've seen). If I touch the Earth I...
Indeterminism in Classical Physics
11 hours ago I was reading the Roger Penrose book Emperor's New Mind and he was explaining the determinism in Newtonian mechanics. He says that if we consider...
- More from Physics Forums - Classical Physics
More news stories
Existing research shows that bicyclists who wear helmets have an 88 percent lower risk of brain injury, but researchers at Boston Children's Hospital found that simply having bicycle helmet laws in place showed a 20 percent ...
Pediatrics May 23, 2013 | not rated yet | 0
(HealthDay)—Over the last decade, the number of American children who die each year awaiting an organ donation dropped by more than half, new research reveals. And increasing numbers of children are receiving ...
Pediatrics May 22, 2013 | not rated yet | 0
Phthalates: Study links chemicals widely found in plastics, processed food to elevated blood pressure in children, teens
Plastic additives known as phthalates (pronounced THAL-ates) are odorless, colorless and just about everywhere: They turn up in flooring, plastic cups, beach balls, plastic wrap, intravenous tubing and—according to the ...
Pediatrics May 22, 2013 | not rated yet | 1 |
A study by Alexandra L. C. Martiniuk, M.Sc, Ph.D., of The George Institute for Global Health, Sydney, Australia, and colleagues suggests less sleep per night is associated with a significant increase in the risk for motor ...
Pediatrics May 20, 2013 | not rated yet | 0
Whole-cell pertussis vaccines were more effective at protecting against pertussis than acellular pertussis vaccines during a large recent outbreak, according to a new Kaiser Permanente study published in Pediatrics.
Pediatrics May 20, 2013 | not rated yet | 0 |
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
8 hours ago | 5 / 5 (3) | 0 |
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
3 hours ago | 5 / 5 (1) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
5 hours ago | 5 / 5 (1) | 0 |
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
6 hours ago | 5 / 5 (2) | 0 |
(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria confined ...
May 23, 2013 | 4.9 / 5 (9) | 0 |
Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.
2 hours ago | not rated yet | 0