Epileptic seizures can propagate using functional brain networks

©2013 Mary Ann Liebert, Inc., publishers

The seizures that affect people with temporal-lobe epilepsy usually start in a region of the brain called the hippocampus. But they are often able to involve other areas outside the temporal lobe, propagating via anatomically and functionally connected networks in the brain. New research findings that link decreased brain cell concentration to altered functional connectivity in temporal-lobe epilepsy are reported in an article in Brain Connectivity, a bimonthly peer-reviewed publication from Mary Ann Liebert, Inc., publishers. .

Martha Holmes and colleagues from Vanderbilt University, Nashville, TN, identified regions in the brains of patients with temporal-lobe epilepsy that had reduced gray-matter concentrations. Greater reductions in gray-matter concentration correlated with either decreased or increased signaling and communication between connected through known functional networks.

The authors present their findings in the article "Functional Networks in Temporal-Lobe Epilepsy: A Voxel-Wise Study of Resting-State and Gray-Matter Concentration."

"This is one of the first studies to actually correlate both functional and structural brain changes in epilepsy," says Christopher Pawela, PhD, Co-Editor-in-Chief and Assistant Professor, Medical College of Wisconsin. "This is an exciting finding and may have impact in other brain disorders in which both the structure and function of the brain are involved."

More information: The article is available free on the Brain Connectivity website at http://www.liebertpub.com/brain

add to favorites email to friend print save as pdf

Related Stories

Autism risk gene linked to differences in brain structure

Mar 21, 2012

Healthy individuals who carry a gene variation linked to an increased risk of autism have structural differences in their brains that may help explain how the gene affects brain function and increases vulnerability ...

Recommended for you

'Chatty' cells help build the brain

9 hours ago

The cerebral cortex, which controls higher processes such as perception, thought and cognition, is the most complex structure in the mammalian central nervous system. Although much is known about the intricate ...

'Trigger' for stress processes discovered in the brain

Nov 27, 2014

At the Center for Brain Research at the MedUni Vienna an important factor for stress has been identified in collaboration with the Karolinska Institutet in Stockholm (Sweden). This is the protein secretagogin ...

New research supporting stroke rehabilitation

Nov 26, 2014

Using world-leading research methods, the team of Dr David Wright and Prof Paul Holmes, working with Dr Jacqueline Williams from the Victoria University in Melbourne, studied activity in an area of the brain ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.