Routine CT imaging can be used to identify osteoporosis

April 17, 2013
Routine CT imaging can be used to identify osteoporosis
Abdominal computed tomography imaging, conducted for other indications, can be used to identify patients with osteoporosis, according to a study published in the April 16 issue of the Annals of Internal Medicine.

(HealthDay)—Abdominal computed tomography (CT) imaging, conducted for other indications, can be used to identify patients with osteoporosis, according to a study published in the April 16 issue of the Annals of Internal Medicine.

Perry J. Pickhardt, M.D., from the University of Wisconsin School of Medicine and Public Health in Madison, and colleagues conducted a cross-sectional study at a single academic health center to compare the value of CT-derived assessment, using CT scans performed for other indications, with dual-energy X-ray absorptiometry (DXA) measures for identifying . Over 10 years, 1,867 adults undergoing CT and DXA within a six-month period were included.

The researchers found that, for patients with DXA-defined osteoporosis, CT-attenuation values were significantly lower at all vertebral levels. Osteoporosis could be distinguished from osteopenia and normal bone mineral density with 90 percent sensitivity with an L1 CT-attenuation threshold of 160 Hounsfield Units (HU) or less, while a threshold of 110 HU was more than 90 percent specific. At L1 CT-attenuation thresholds less than 100 HU, the positive predictive values for osteoporosis were 68 percent or greater; at thresholds greater than 200 HU, the negative predictive values were 99 percent. Most of the 119 patients with one or more moderate-to-severe had nonosteoporotic T-scores (52.1 percent), and 97 percent had L1 or mean T12 to L5 vertebral attenuation of 145 HU or less.

"In conclusion, we demonstrate how routine abdominal CT scans obtained for other clinical indications can be used for opportunistic osteoporosis screening without the need for additional imaging, , cost, equipment, or patient time," the authors write.

Two authors disclosed financial ties to the pharmaceutical and/or diagnostic industry.

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Once-yearly zoledronic acid benefits men with osteoporosis

November 2, 2012

(HealthDay)—For men with osteoporosis, a once-yearly infusion with zoledronic acid is associated with fewer vertebral fractures and improved bone health compared with placebo, according to a study published in the Nov. ...

Lowering CT tube voltage for colonography beneficial

March 7, 2013

(HealthDay)—In patients undergoing computed tomography (CT) colonography, reducing the tube voltage from 120 kVp to 100 kVp significantly reduces radiation dose while minimally reducing image quality, regardless of patient ...

Multiple cone-beam scans fall within acceptable ranges

March 14, 2013

(HealthDay)—The radiation dose imparted to patients undergoing multiple intraoperative lumbar single cone-beam computed tomography (CT) scans is within the dose range that patients receive during a single fan-beam abdominal ...

Recommended for you

Study reveals new insight into DNA repair

August 3, 2015

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy. New information published this week reveals more about why this occurs and how these breaks ...

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.