Evolution of an outbreak: Complications from contaminated steroid injections

A study of the patients who received injections of steroids contaminated with the fungus Exserohilum rostratum from the New England Compounding Center has found that some patients had fungal infections even though they did not experience a worsening of their symptoms and that magnetic resonance imaging (MRI) can help detect infection, especially among those individuals who received injections from highly contaminated lots.

The study, along with an editorial by UC Davis Assistant Professor of Medical Microbiology and Immunology George R. Thompson, appears in the June 19 issue of the Journal of the American Medical Association.

"The study shows that exposed to the contaminated steroids can no longer be reassured that the lack of new or progressive symptoms equates to a lack of fungal infection," Thompson said. "Exposed patients may have paraspinal or spinal infections even though they do not notice any increase in pain or neuropathic symptoms. at the injection site is recommended to screen for infection in high-, but it should not be widely adopted, particularly for patients who received injections in peripheral joints, which the study associated with a much lower attack rate."

In the fall of 2012, the U.S. (CDC), in collaboration with state and local health departments and the (FDA), began investigating an unprecedented multistate outbreak of among patients who received contaminated for the treatment of back pain or neuropathic symptoms. While meningitis was the primary complication after the initial steroid injection, spinal or paraspinal infections can surface weeks to months later. To date, more than 740 patients in 20 states have been diagnosed with meningitis, spinal or paraspinal infections, joint infections or other complications at or near the injection site linked with compouding pharmacy formulations. Patients who received injections in peripheral joints only, such as the knee, shoulder or ankle, could be at risk for joint infection and are also included in the investigation.

"Continued vigilance and collaborative efforts with radiologists experienced in interpreting MRI findings of E rostratum are needed to detect late fungal infections in patients to improve health outcomes," Thompson said.

According to the CDC, Exserohilum is a common mold found in soil and on plants, especially grasses, and it thrives in warm and humid climates. While it is a very rare cause of infection in people, the mold has been known to cause several different types of infections, including infection in the skin or the cornea (the clear, front part of the eye), which are typically due to skin or eye trauma. Exserohilum can also cause more invasive forms of infection in the sinuses, lungs, lining of the heart and bone, which are thought to be more likely to occur in people with weak immune systems.

More information: jama.jamanetwork.com/article.a… px?articleid=1697964
jama.jamanetwork.com/article.a… px?articleid=1697947

add to favorites email to friend print save as pdf

Related Stories

Study examines outbreak of spinal infections in Michigan

May 21, 2013

(HealthDay)—Factors such as increased case finding may explain why Michigan had half of the total spinal infections associated with contaminated methylprednisolone acetate in the recent fungal meningitis ...

Fungal meningitis deaths rise to 24, CDC reports

Oct 25, 2012

The U.S. Centers for Disease Control and Prevention reported Wednesday that a 24th person had died of fungal meningitis after receiving contaminated steroid injections. The latest victim had received an injection to treat ...

Recommended for you

Ebola in mind, US colleges screen some students

Aug 29, 2014

University students from West Africa may be subject to extra health checks when they arrive to study in the United States as administrators try to insulate their campuses from the worst Ebola outbreak in ...

User comments