Uncovering a healthier remedy for chronic pain

Uncovering a healthier remedy for chronic pain
A compound derived from the DHA in fish oil -- Protectin D1 (PD1/NPD1) -- offers protection from nerve trauma-induced neuropathic pain by preventing neuronal and glial hyperactivity in the spinal cord. Glial cells, when activated, produce proinflammatory cytokines that may further damage the nerve cells. Credit: Ru-Rong Ji and Zhen-Zhong Xu, Duke University Medical Center

Physicians and patients who are wary of addiction to pain medication and opioids may soon have a healthier and more natural alternative.

A Duke University study revealed that a derivative of DHA (docosahexaenoic acid), a main ingredient of over-the-counter , can sooth and prevent neuropathic pain caused by injuries to the sensory system. The results appear online in the Annals of Neurology.

The research focused on a compound called neuroprotectin D1=protectin D1 (NPD1=PD1), a bioactive lipid produced by cells in response to . NPD1=PD1 is present in human , and was first identified based on its ability to resolve abdominal and .

"These compounds are derived from omega-3 fatty acids found in fish oil, but are 1,000 times more potent than their precursors in reducing inflammation," said Ru-Rong Ji, professor of anesthesiology and neurobiology at Duke University Medical Center and principal investigator of the study.

The team used laboratory mouse models of to simulate pain symptoms commonly associated with post-surgical nerve trauma. They treated these animals with chemically-synthesized NPD1=PD1, either through local administration or injection, to investigate whether the lipid compound could relieve these symptoms.

Their findings revealed that NPD1=PD1 not only alleviated the pain, but also reduced nerve swelling following the injuries. Its analgesic effect stems from the compound's ability to inhibit the production of cytokines and chemokines, which are small signaling molecules that attract inflammatory macrophages to the . By preventing cytokine and chemokine production, the compound protected nerve cells from further damage. NPD1=PD1 also reduced neuron firing so the injured animals felt less pain.

Ji believes that the new discovery has clinical potential. "Chronic pain resulting from major medical procedures such as amputation, chest and is a serious problem," he said. Current treatment options for neuropathic pain include gabapentin and various opioids, which may lead to addiction and destruction of the sensory nerves.

On the other hand, NPD1=PD1 can relieve neuropathic pain at very low doses and, more importantly, mice receiving the treatment did not show signs of physical dependence or enhanced tolerance toward the lipid compound.

"We hope to test this compound in clinical trials," Ji said. The initial stages of the trial could involve DHA administration through diet and injection. "DHA is very inexpensive, and can be converted to NPD1 by an aspirin-triggered pathway," he said. The ultimate goal is to develop a safer approach to managing chronic pain.

More information: Annals of Neurology, online May 18, 2013. DOI: 10.1002/ana.23928

Related Stories

How does exercise affect nerve pain?

date Jun 01, 2012

Exercise helps to alleviate pain related to nerve damage (neuropathic pain) by reducing levels of certain inflammation-promoting factors, suggests an experimental study in the June issue of Anesthesia & Analgesia, offici ...

Fatty acids could lead to flu drug

date Mar 07, 2013

Flu viruses are a major cause of death and sickness around the world, and antiviral drugs currently do not protect the most seriously ill patients. A study published March 7th by Cell Press in the journal Cell reveals that a ...

New insight into pain mechanisms

date Apr 25, 2012

(Medical Xpress) -- Researchers in the UCL Wolfson Institute for Biomedical Research have made a discovery which could help the development of analgesic drugs able to treat nerve damage-related pain.

Recommended for you

The coming merge of human and machine intelligence

date 11 hours ago

For most of the past two million years, the human brain has been growing steadily. But something has recently changed. In a surprising reversal, human brains have actually been shrinking for the last 20,000 ...

How the brain makes decisions

date 12 hours ago

Some types of decision-making have proven to be very difficult to simulate, limiting progress in the development of computer models of the brain. EPFL scientists have developed a new model of complex decision-making, ...

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

PeterD
Jul 18, 2013
Surprise, surprise! That's why I have taken fish oil for years.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.