Researchers invent portable device for common kidney tests

UCLA researchers invent portable device for common kidney tests
The smartphone display and portable albumin tester created by the Ozcan Research Group at the UCLA Henry Samueli School of Engineering and Applied Science. Credit: Ozcan Research Group

(Medical Xpress)—A lightweight and field-portable device invented at UCLA that conducts kidney tests and transmits data through a smartphone attachment may significantly reduce the need for frequent office visits by people with diabetes and others with chronic kidney ailments.

The smartphone-based device was developed in the research lab of Aydogan Ozcan, a professor of electrical engineering and bioengineering at the UCLA Henry Samueli School of Engineering and Applied Science, and associate director of the California NanoSystems Institute. Weighing about one-third of a pound, the gadget can determine levels of in the patient's urine and transmit the results within seconds. Albumin is a protein in blood that is a sign of danger when found in urine. 

Ozcan's lab also developed the opto-mechanical phone attachment, disposable test tubes, Android app and software to transmit the data. The research was published this month by the peer-reviewed journal Lab on a Chip.

"Albumin testing is frequently done to assess , especially for ," Ozcan said. "This device provides an extremely convenient platform for chronic patients at home or in remote locations where cell phones work."

Patients at risk for diabetes, and other ailments must regularly provide fluid samples—sometimes more than one a day—to monitor their health, which requires visits to labs or health centers.

The new device projects beams of visible light through two small fluorescent tubes attached to the device, one containing a control liquid and the other a urine sample mixed with . The smartphone camera captures the fluorescent light after it passes through an additional lens. 

An Android application then processes the raw images in less than one second and the device transmits the test results to a database or . The test, which measures albumin concentration in urine, is accurate to within less than 10 micrograms per milliliter, according to the research, well within accepted clinical standards used in diagnosing conditions such as microalbuminuria, the excretion of albumin in urine.

The time it takes to conduct a test, including preparation of a sample using a small syringe to inject the urine into a fluorescent tube, is about five minutes. Ozcan estimates that the device—for which his lab also has developed an iPhone app—could be produced commercially for $50 to $100 per unit.

Related Stories

n-3 PUFA may reduce markers of kidney disease in T2DM

Feb 08, 2013

(HealthDay)—In patients with type 2 diabetes and evidence of kidney injury, supplementation with n-3 long-chain polyunsaturated fatty acids (PUFA) does not reduce urine albumin excretion but is associated ...

Uric acid may provide early clues to diabetic kidney disease

Mar 18, 2008

For patients with type 1 diabetes, increased levels of uric acid in the blood may be an early sign of diabetic kidney disease—appearing before any significant change in urine albumin level, the standard screening test, ...

Recommended for you

Sierra Leone faces criticism over Ebola shutdown

14 hours ago

Sierra Leone began the second day of a 72-hour nationwide shutdown aimed at containing the spread of the deadly Ebola virus on Saturday amid criticism that the action was a poorly planned publicity stunt.

Presence of peers ups health workers' hand hygiene

Sep 19, 2014

(HealthDay)—The presence of other health care workers improves hand hygiene adherence, according to a study published in the October issue of Infection Control and Hospital Epidemiology.

Sierra Leone streets deserted as shutdown begins

Sep 19, 2014

Sierra Leone's normally chaotic capital resembled a ghost town on Friday as residents were confined to their homes for the start of a three-day lockdown aimed at halting the deadly Ebola epidemic.

Sierra Leone launches controversial Ebola shutdown

Sep 19, 2014

Sierra Leone on Friday launched a controversial three-day shutdown to contain the deadly spread of the Ebola virus, as the UN Security Council declared the deadly outbreak a threat to world peace.

User comments