Brazil to test new vaccine against dengue fever

Brazilian scientists will next month begin clinical tests on humans of a new vaccine against dengue fever, a leading Sao Paulo-based biomedical research institute said Thursday.

The is being developed to combat the four closely related strains of dengue viruses that have been identified around the world, the Butantan institute said in a statement.

Brazil is frequently afflicted with the disease, which is spread by the mosquito Aedes aegypti.

Work on the vaccine began in 2005 in partnership with the US National Institutes of Health (NIH), Butantan said.

In a first phase, the vaccine was tested on animals and humans in the United States and produced a good immunological response, it noted.

The second phase is to begin in October with on 300 Brazilian volunteers, all healthy adults aged between 18 and 59 of both sexes, over a five-year period.

The institute said the vaccine is expected to be ready by 2018.

"This new phase is very important because it will be adapted to the particular characteristics of the Brazilian population," said Butantan Director Jorge Kalil.

"The production of a Brazilian vaccine for is a major advance for public health," said Sao Paulo state Giovanni Guido Cerri.

"We are making major strides toward producing a safe, effective and low-cost vaccine which can be incorporated into the National Immunization Program and meet the entire Brazilian demand."

Dengue fever affects between 50 and 100 million people in the tropics and subtropics each year, causing fever, muscle and joint ache as well as potentially fatal dengue hemorrhagic fever and dengue shock syndrome.

Researchers estimate that around three billion people in the world live in regions susceptible to dengue contagion and another 20 million tourists pass through them.

Butantan, which has a long tradition of research on snakes and poisonous animals, is the leading domestic producer of anti-venom sera and vaccines.

Related Stories

Brazil to breed GM mosquitoes to combat dengue

date Jul 10, 2012

Brazil said Monday it will breed huge numbers of genetically modified mosquitoes to help stop the spread of dengue fever, an illness that has already struck nearly 500,000 people this year nationwide.

Dengue fever outbreak hits Costa Rica

date Apr 10, 2013

Health officials in Costa Rica said an outbreak of dengue fever has sickened 7,000 people, with many cases occurring in some of this Central American country's most popular tourist areas.

Dengue raises alarm in Central America

date Jul 03, 2013

Authorities have issued dengue alerts in four nations across Central America, where alarm is rising as the mosquito-borne disease has infected 30,000 people and killed 17 this year alone.

Concerns over cost of dengue vaccine lessened with new study

date Jun 28, 2012

Research funded by the Dengue Vaccine Initiative (DVI) involving an economic analysis of producing a tetravalent dengue vaccine shows that the cost could be as low as $0.20 per dose with an annual production level of 60 million ...

Recommended for you

Rapamune approved for rare lung disease

date 7 hours ago

(HealthDay)—Rapamune (sirolimus) has been approved by the U.S. Food and Drug Administration to treat a rare, progressive lung disease that mostly affects women of childbearing age.

FDA warns of complications from facial fillers

date 8 hours ago

(HealthDay)—Soft tissue fillers used in cosmetic procedures can accidentally be injected into blood vessels in the face and cause serious harm, the U.S. Food and Drug Administration warns.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.