Pediatric musculoskeletal MRSA infections on the rise

October 26, 2013

Pediatric musculoskeletal Staphylococcus aureus bacterial infections have been evolving over the past decade, with more children diagnosed with the more virulent, methicillin-resistant Staphylococcus aureus (MRSA) today than 10 years ago. The result is longer hospitals stays, more surgeries and other related complications, according to an abstract presented Saturday, Oct. 26, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in Orlando.

In "Staphylococcus Aureus Musculoskeletal Infections: A Changing Spectrum over the Past Decade," researchers studied pediatric patients with culture-positive Staphylococcus aureus, including MRSA and the less toxic methicillin-sensitive Staphylococcus aureus (MSSA), between January 2001 and June 2010, at a major urban children's hospital.

There were 148 cases of acute musculoskeletal Staphylococcus aureus , including 111 MSSA and 37 MRSA, with the proportion of MRSA cases jumping from 9 percent in 2001 to 29 percent (three-fold) in 2010. The MRSA-infected patients had longer hospital stays (13 days vs. 8 days), multiple surgical procedures (38 percent vs. 15 percent), and higher levels of C-Reactive Protein, the body's acute immune response to injury and infection, (38 percent vs. 15 percent). Complications, including deep vein thrombosis, septic emboli and septic shock, recurrent infection, and/or avascular necrosis, or cell death, were more common in patients with MRSA than MSSA infections (22 percent vs. 6 percent).

"As MRSA infections rise, prompt recognition and aggressive treatment of MRSA musculoskeletal infections are critical to avoiding life-threatening complications, and improving patient outcomes," said lead study author Eric Sarkissian.

"Our findings support prior concern about the increased virulence of MRSA compared to MSSA infections," said Sarkissian. "Optimizing patient outcomes will require increased healthcare provider vigilance, early broad-spectrum antibiotic administration and aggressive surgical management."

Explore further: Relative proportion of MRSA increasing in S. aureus isolates

Related Stories

Staph sepsis increases mortality in preterm infants

March 12, 2012

(HealthDay) -- Only about 1 percent of very low birth weight (VLBW) infants develop methicillin-resistant Staphylococcus aureus (MRSA) infections, and the morbidity and mortality are similar to that seen in infants with methicillin-susceptible ...

MRSA colonization in groin tied to clinical infections

March 26, 2013

(HealthDay)—Groin colonization of methicillin-resistant Staphylococcus aureus (MRSA) leads to an increased risk of developing active MRSA infection later among HIV-infected patients, according to a study published in the ...

Copious community-associated MRSA in nursing homes

October 24, 2013

More than one quarter of residents of 26 nursing homes in Orange County, California carry community-associated methicillin-resistant Staphylococcus aureus (MRSA), which spread more easily, and may cause more severe infection ...

MRSA skin infections up, linked to furunculosis

July 27, 2012

(HealthDay) -- The incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in the United States is increasing and is associated with follicular infection, most commonly folliculitis followed ...

Recommended for you

Zika virus infection alters human and viral RNA

October 20, 2016

Researchers at University of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and human genetic material. These modifications—chemical tags known as ...

Food-poisoning bacteria may be behind Crohn's disease

October 19, 2016

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University.

Neurodevelopmental model of Zika may provide rapid answers

October 19, 2016

A newly published study from researchers working in collaboration with the Regenerative Bioscience Center at the University of Georgia demonstrates fetal death and brain damage in early chick embryos similar to microcephaly—a ...

Scientists uncover new facets of Zika-related birth defects

October 17, 2016

In a study that could one day help eliminate the tragic birth defects caused by Zika virus, scientists from the Florida campus of The Scripps Research Institute (TSRI) have elucidated how the virus attacks the brains of newborns, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.