Synthetic vitamin D receptor ligands reduce murine kidney fibrosis

Vitamin D deficiency has been associated with kidney disease including fibrosis. Some studies have even suggested that treatment with vitamin D or vitamin D analogs can reduce renal fibrosis; however, the pathways targeted by vitamin D therapy are not completely understood.

In this issue of the Journal of Clinical Investigation, Junn Yanagisawa and colleagues at the University of Tsukuba found that D binding to its receptor inhibited the TGF-β/SMAD signaling pathway and prevented renal fibrosis in mice.

The authors then generated a synthetic ligand of the vitamin D receptor that, like vitamin D, reduced renal fibrosis; however, unlike vitamin D, this synthetic ligand did not promote hypercalcemia.

In the accompanying commentary Joseph Bonventre suggests that synthetic ligands of the vitamin D receptor should be further studied as therapeutics for patients with fibrotic diseases.

More information: A nonclassical vitamin D receptor pathway suppresses renal fibrosis, J Clin Invest. DOI: 10.1172/JCI67804
Antifibrotic vitamin D analogs, J Clin Invest. 2013;123(11):4570–4573. DOI: 10.1172/JCI72748

add to favorites email to friend print save as pdf

Related Stories

Can vitamin B supplements help stave off stroke?

Sep 18, 2013

New evidence suggests that taking vitamin B supplements may help reduce the risk of stroke. The research appears in the September 18, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurol ...

Who benefits from vitamin D?

Aug 13, 2013

Studying the expression of genes that are dependent on vitamin D makes it possible to identify individuals who will benefit from vitamin D supplementation, shows a University of Eastern Finland study published recently in ...

Recommended for you

Infertility, surrogacy in India

47 minutes ago

Infertility is a growing problem worldwide. A World Health Organization report estimates that 60-to-80 million couples worldwide currently suffer from infertility.

Tooth loss linked to slowing mind and body

13 hours ago

The memory and walking speeds of adults who have lost all of their teeth decline more rapidly than in those who still have some of their own teeth, finds new UCL research.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.