Synthetic vitamin D receptor ligands reduce murine kidney fibrosis

Vitamin D deficiency has been associated with kidney disease including fibrosis. Some studies have even suggested that treatment with vitamin D or vitamin D analogs can reduce renal fibrosis; however, the pathways targeted by vitamin D therapy are not completely understood.

In this issue of the Journal of Clinical Investigation, Junn Yanagisawa and colleagues at the University of Tsukuba found that D binding to its receptor inhibited the TGF-β/SMAD signaling pathway and prevented renal fibrosis in mice.

The authors then generated a synthetic ligand of the vitamin D receptor that, like vitamin D, reduced renal fibrosis; however, unlike vitamin D, this synthetic ligand did not promote hypercalcemia.

In the accompanying commentary Joseph Bonventre suggests that synthetic ligands of the vitamin D receptor should be further studied as therapeutics for patients with fibrotic diseases.

More information: A nonclassical vitamin D receptor pathway suppresses renal fibrosis, J Clin Invest. DOI: 10.1172/JCI67804
Antifibrotic vitamin D analogs, J Clin Invest. 2013;123(11):4570–4573. DOI: 10.1172/JCI72748

add to favorites email to friend print save as pdf

Related Stories

Can vitamin B supplements help stave off stroke?

Sep 18, 2013

New evidence suggests that taking vitamin B supplements may help reduce the risk of stroke. The research appears in the September 18, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurol ...

Who benefits from vitamin D?

Aug 13, 2013

Studying the expression of genes that are dependent on vitamin D makes it possible to identify individuals who will benefit from vitamin D supplementation, shows a University of Eastern Finland study published recently in ...

Recommended for you

ER waiting times vary significantly, studies find

4 hours ago

(HealthDay)—When it comes to emergency room waiting times, patients seeking care at larger urban hospitals are likely to spend more time staring down the clock than those seen at smaller or more rural facilities, ...

Internists report considerable EMR-linked time loss

4 hours ago

(HealthDay)—Use of electronic medical record (EMR) systems is associated with considerable loss of free time per clinic day, according to a research letter published online Sept. 8 in JAMA Internal Medicine.

Kids eat better if their parents went to college

4 hours ago

Children of college-educated parents eat more vegetables and drink less sugar, according to a new study from the University of British Columbia. But it's still not enough, the study goes on to say, as all kids are falling ...

User comments