A mouse model to evaluate potential age-promoting compounds

While there are well-established mouse models to identify cancer-causing agents, similar models are not available to readily test and identify age-promoting agents. Recently, a mouse strain (p16LUC mice) was developed that can be used to evaluate the transcription of p16INK4, which is increasingly expressed during aging and in age-associated diseases.

In this issue of the Journal of Clinical Investigation, Norman Sharpless and colleagues at the University of North Carolina evaluated potential age-promoting compounds, including arsenic, a high-fat diet, UV light, and in p16LUC mice.

The authors found that a high fat diet did not accelerate p16INK4 expression, but both UV light exposure and cigarette smoke exposure dramatically increased p16INK4 expression compared to controls that had not been exposed to these age-promoting compounds.

This study demonstrates that p16LUC mice are an appropriate model system for evaluating potential age-promoting compounds.

More information: p16INK4a reporter mice reveal age-promoting effects of environmental toxicants, J Clin Invest. DOI: 10.1172/JCI70960

add to favorites email to friend print save as pdf

Related Stories

A lifespan-extending drug has limited effects on aging

Jul 25, 2013

The immunosuppressive drug rapamycin has been shown to increase longevity in mice even when treatment begins at an advanced age. It is unclear if the extension of life also correlates with prolonged health and vigor.

Early COPD diagnosis possible with nuclear medicine

Apr 01, 2013

In vivo ventilation/perfusion (V/Q) imaging can detect early changes to the lung caused by cigarette smoke exposure and provides a noninvasive method for studying lung dysfunction in preclinical models, according to research ...

Secondhand smoke results in graft rejection

Feb 23, 2012

A new study published in the American Journal of Transplantation reveals that cigarette smoke exposure, in a cause-effect manner, results in graft rejection that would have been prevented by certain drug treatments.

Recommended for you

A new way to diagnose malaria, using magnetic fields

20 hours ago

Over the past several decades, malaria diagnosis has changed very little. After taking a blood sample from a patient, a technician smears the blood across a glass slide, stains it with a special dye, and ...

How Alzheimer's peptides shut down cellular powerhouses

Aug 29, 2014

The failing in the work of nerve cells: An international team of researchers led by Prof. Dr. Chris Meisinger from the Institute of Biochemistry and Molecular Biology of the University of Freiburg has discovered ...

User comments