A mouse model to evaluate potential age-promoting compounds

December 16, 2013

While there are well-established mouse models to identify cancer-causing agents, similar models are not available to readily test and identify age-promoting agents. Recently, a mouse strain (p16LUC mice) was developed that can be used to evaluate the transcription of p16INK4, which is increasingly expressed during aging and in age-associated diseases.

In this issue of the Journal of Clinical Investigation, Norman Sharpless and colleagues at the University of North Carolina evaluated potential age-promoting compounds, including arsenic, a high-fat diet, UV light, and in p16LUC mice.

The authors found that a high fat diet did not accelerate p16INK4 expression, but both UV light exposure and cigarette smoke exposure dramatically increased p16INK4 expression compared to controls that had not been exposed to these age-promoting compounds.

This study demonstrates that p16LUC mice are an appropriate model system for evaluating potential age-promoting compounds.

More information: p16INK4a reporter mice reveal age-promoting effects of environmental toxicants, J Clin Invest. DOI: 10.1172/JCI70960

Related Stories

Secondhand smoke results in graft rejection

February 23, 2012

A new study published in the American Journal of Transplantation reveals that cigarette smoke exposure, in a cause-effect manner, results in graft rejection that would have been prevented by certain drug treatments.

Early COPD diagnosis possible with nuclear medicine

April 1, 2013

In vivo ventilation/perfusion (V/Q) imaging can detect early changes to the lung caused by cigarette smoke exposure and provides a noninvasive method for studying lung dysfunction in preclinical models, according to research ...

A lifespan-extending drug has limited effects on aging

July 25, 2013

The immunosuppressive drug rapamycin has been shown to increase longevity in mice even when treatment begins at an advanced age. It is unclear if the extension of life also correlates with prolonged health and vigor.

Recommended for you

Flow means 'go' for proper lymph system development

July 27, 2015

The lymphatic system provides a slow flow of fluid from our organs and tissues into the bloodstream. It returns fluid and proteins that leak from blood vessels, provides passage for immune and inflammatory cells from the ...

Fluorescent material reveals how cells grow

July 21, 2015

Fibre from a semiconducting polymer, developed for solar cells, is an excellent support material for the growth of new human tissue. Researchers at Linköping University have shown that the fibre glows, which makes it possible ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.