Pre-op MRI of margins predicts rectal cancer outcomes

December 8, 2013
Pre-op MRI of margins predicts rectal cancer outcomes

(HealthDay)—Preoperative high-resolution magnetic resonance imaging (MRI) assessment of circumferential resection margin (CRM) status predicts survival and other disease progression outcomes in patients with rectal cancer, according to a study published online Nov. 25 in the Journal of Clinical Oncology.

Fiona G.M. Taylor, from Mayday University Hospital in Croydon, U.K., and colleagues conducted a follow-up study in 374 patients with . Preoperative high-resolution pelvic MRIs were used to assess CRM, and the relationship of MRI assessment and outcomes were evaluated.

The researchers found that five-year overall survival (OS) was 62.2 percent in patients with MRI-clear CRM compared to 42.2 percent in patients with MRI-involved CRM (hazard ratio, 1.97). Disease-free survival (DFS) at five years was 67.2 percent for MRI-clear CRM versus 47.3 percent for MRI-involved CRM (hazard ratio, 1.65). For MRI-involved CRM, local recurrence (LR) was 3.50. In multivariate analysis, MRI-involved CRM was the only preoperative staging parameter that remained significant for OS, DFS, and LR.

"High-resolution MRI preoperative assessment of CRM status is superior to American Joint Committee on Cancer TNM-based criteria for assessing risk of LR, DFS, and OS," the authors write.

Explore further: MRI predicts survival in locally advanced rectal cancer

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

MRI predicts survival in locally advanced rectal cancer

August 29, 2011

A new study has shown that magnetic resonance imaging (MRI) used to evaluate responses to pre-surgery (neo-adjuvant) chemotherapy or radiation may predict survival among patients with advanced rectal cancer. The findings ...

High-dose rhBMP linked to increased incidence of cancer

October 4, 2013

(HealthDay)—Patients receiving high-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) as part of spine surgery have an increased risk of cancer and may be at risk for major complications, according to two studies ...

Recommended for you

Study: Enhancing cancer response to radiation

December 2, 2016

OHSU researcher Sudarshan Anand, Ph.D., has a contemporary analogy to describe microRNA: "I sometimes compare MicroRNA to tweets—they're short, transient and constantly changing."

Rare childhood disease linked to major cancer gene

December 1, 2016

A team of researchers led by a University of Rhode Island scientist has discovered an important molecular link between a rare childhood genetic disease, Fanconi anemia, and a major cancer gene called PTEN. The discovery improves ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.