Exercise ups mitochondrial biogenesis in adipose tissue

Exercise ups mitochondrial biogenesis in adipose tissue

(HealthDay)—Exercise training increases mitochondrial biogenesis, mitochondrial DNA (mtDNA) content, and glucose uptake in the subcutaneous adipose tissue of wild type, but not endothelial nitric oxide synthase (eNOS) knockout mice, according to research published online March 12 in Diabetes.

Elisabetta Trevellin, Ph.D., of the University of Padua in Italy, and colleagues conducted studies in mice and cell cultures of murine and human adipocytes to investigate the effects of exercise on mitochondria and glucose metabolism in adipose tissue.

The researchers found that swim training resulted in in vivo effects of increases in mitochondrial biogenesis, mtDNA uptake, and glucose uptake in of wild type, but not eNOS knockout, mice. In vitro studies showed that treatment with a donor stimulated mitochondrial biogenesis and elongation as well as and GLUT4 translocation in cultured murine and human adipocytes.

"These results point to the crucial role of the eNOS-derived nitric oxide in the metabolic adaptation of subcutaneous adipose tissue to exercise training," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Telmisartan reverses insulin resistance in mice

date Jan 03, 2013

(HealthDay)—Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ (PPAR-δ) gene is present, ...

Have brain fatigue? A bout of exercise may be the cure

date Sep 19, 2011

Researchers have long known that regular exercise increases the number of organelles called mitochondria in muscle cells. Since mitochondria are responsible for generating energy, this numerical boost is thought to underlie ...

Exercise protects the heart via nitric oxide

date May 04, 2011

Exercise both reduces the risk of a heart attack and protects the heart from injury if a heart attack does occur. For years, doctors have been trying to dissect how this second benefit of exercise works, with the aim of finding ...

Recommended for you

Faster heart rate linked to diabetes risk

date May 22, 2015

An association between resting heart rate and diabetes suggests that heart rate measures could identify individuals with a higher future risk of diabetes, according to an international team of researchers.

EBV co-infection may boost malaria mortality in childhood

date May 21, 2015

Many people who live in sub-Saharan Africa develop a natural immunity to malaria, through repeated exposure to Plasmodium parasites. Even so, the disease kills close to half a million children per year, according ...

Three important things you didn't know about diabetes

date May 21, 2015

When we think of diabetes, we tend to think of rich people with poor lifestyles. A chronic disease linked with obesity, heart disease and worse outcomes for some infectious diseases, diabetes tends to be ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.