Inflammation tied to depressive symptoms in new T2DM

May 30, 2014
Inflammation tied to depressive symptoms in new T2DM

(HealthDay)—For patients with newly diagnosed type 2 diabetes, inflammatory markers are associated with depressive symptoms, according to a study published online May 19 in Diabetes Care.

Jean-Pierre S. Laake, from King's College London, and colleagues examined the correlation between depressive symptoms in adults and newly diagnosed type 2 diabetes and concentrations of . Depressive symptoms were assessed using the Patient Health Questionnaire-9. Twelve markers of inflammation were measured in 1,790 participants recruited from primary care.

The researchers found that depressive symptoms were associated with C-reactive protein (P < 0.001); interleukin (IL)-1β (P = 0.047); IL-1 receptor antagonist (P < 0.001); monocyte chemotactic protein-1 (P = 0.001); white (P < 0.001); and triglycerides (P < 0.001). These correlations were seen after adjustment for covariates, including sociodemographic factors, adiposity, macrovascular disease, glycated hemoglobin, and prescribed medication.

"Increased inflammation may be involved in the pathogenesis of in type 2 diabetes and contribute to the increased risk of complications and mortality in this group," the authors write.

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