Inflammation tied to depressive symptoms in new T2DM

May 30, 2014
Inflammation tied to depressive symptoms in new T2DM

(HealthDay)—For patients with newly diagnosed type 2 diabetes, inflammatory markers are associated with depressive symptoms, according to a study published online May 19 in Diabetes Care.

Jean-Pierre S. Laake, from King's College London, and colleagues examined the correlation between depressive symptoms in adults and newly diagnosed type 2 diabetes and concentrations of . Depressive symptoms were assessed using the Patient Health Questionnaire-9. Twelve markers of inflammation were measured in 1,790 participants recruited from primary care.

The researchers found that depressive symptoms were associated with C-reactive protein (P < 0.001); interleukin (IL)-1β (P = 0.047); IL-1 receptor antagonist (P < 0.001); monocyte chemotactic protein-1 (P = 0.001); white (P < 0.001); and triglycerides (P < 0.001). These correlations were seen after adjustment for covariates, including sociodemographic factors, adiposity, macrovascular disease, glycated hemoglobin, and prescribed medication.

"Increased inflammation may be involved in the pathogenesis of in type 2 diabetes and contribute to the increased risk of complications and mortality in this group," the authors write.

Explore further: High total, animal protein intake ups type 2 diabetes risk

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Glycemic variability elevates risk of vascular events, death

May 16, 2014

(HealthDay)—Visit-to-visit variability (VVV) in glycated hemoglobin (HbA1c) and fasting glucose correlate with major adverse outcomes for patients with type 2 diabetes, according to a study published online May 8 in Diabetes ...

Collaborative depression care beneficial in ob-gyn clinics

May 15, 2014

(HealthDay)—An evidence-based collaborative depression care intervention adapted to obstetrics and gynecology clinics improves depressive and functional outcomes compared with usual care, according to a study published ...

Low insulin secretion tied to depressive symptoms in women

December 29, 2012

(HealthDay)—Middle-aged women with insulin secretion levels in the lowest quintile appear to have more than twice the risk of developing new-onset depressive symptoms compared with those with higher insulin secretion levels, ...

Vitamin D supplementation may be beneficial in depression

April 7, 2014

(HealthDay)—Vitamin D supplementation has no overall effect on depressive symptoms, but may have a significant effect for those with clinically significant depression, according to a review published online March 14 in ...

Recommended for you

New theory on how insulin resistance, metabolic disease begin

September 26, 2016

Does eating too much sugar cause type 2 diabetes? The answer may not be simple, but a study published Sept. 26 in the Journal of Clinical Investigation adds to growing research linking excessive sugar consumption—specifically ...

Unique molecular atlas of pancreas produced

September 23, 2016

Researchers at Karolinska Institutet have managed to produce the first molecular map of the genes that are active in the various cells of the human pancreas. They have also revealed differences in genetic activity between ...

Can long naps cause diabetes?

September 14, 2016

A study presented at a scientific congress Thursday reported a link between long naps and a higher risk of diabetes, though it couldn't say if daytime sleeping was a symptom or a cause.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.