Cancer grading gets an upgrade

by Rosie Hales
Cancer grading gets an upgrade
A microscope view of prostate cancer. Credit: David M. Berman, 2014.

(Medical Xpress)—Prostate cancer is the second most commonly diagnosed cancer among Canadian men but only about half of these cancers grow rapidly enough to require treatment.

However, determining which prostate cancers need to be treated can be tricky because it's hard to predict through biopsy which cancers will eventually become harmful. In fact, because biopsies often do not yield accurate information, between a third and half of patients initially diagnosed with harmless prostate cancers are likely to be "upgraded" to potentially harmful cancers within a year or two of diagnosis.

A research team led by Dr. David Berman, a professor in the Department of Pathology and Molecular Medicine at Queen's, and Dr. Tamara Lotan from Johns Hopkins University discovered that the decline of a specific protein within a tumour could help identify the tumours requiring treatment.

"We have shown that a tumour-suppressing protein called phosphatase and tensin homolog, or PTEN, is lost most frequently in prostate tumours that will become harmful and require treatment," says Dr. Berman. "The team from Johns Hopkins has done a terrific job of making this test more reliable and valid and applicable to prostate cancer and to other forms of cancer."Currently, the Gleason Grading system is used to determine the harmful potential of prostate cancers. Scores usually range from 6 to 10, with lower numbers often indicating cancers that are unlikely to become harmful.

One hundred and seventy four patients with a Gleason score of 6 had The team measured PTEN levels in cancers biopsied from 174 patients, who appeared to have harmless cancers with Gleason scores of 6 or less. Seventy-one of these cases were upgraded to potentially harmful cancers with a score of 7 after the entire was surgically removed and examined by pathologists. Importantly, PTEN loss found in biopsies helped separate harmless cancers from their more dangerous look-alikes.

"The 71 patients who had their tumours upgraded had a three times higher rate of PTEN loss than the group that was accurately graded," says Dr. Berman. "Although the percentage of who have PTEN loss is low, this finding is extremely exciting as it proves that measuring proteins in biopsies can improve accuracy. Also, it's a fairly simple test that could be done in any pathology lab."

Related Stories

Prostate cancer biomarkers identified in seminal fluid

date Jun 06, 2014

(Medical Xpress)—Improved diagnosis and management of one of the most common cancers in men - prostate cancer - could result from research at the University of Adelaide, which has discovered that seminal ...

Recommended for you

Spicy treatment the answer to aggressive cancer?

date 1 hour ago

It has been treasured by food lovers for thousands of years for its rich golden colour, peppery flavour and mustardy aroma…and now turmeric may also have a role in fighting cancer.

Cancer survivors who smoke perceive less risk from tobacco

date 18 hours ago

Cancer survivors who smoke report fewer negative opinions about smoking, have more barriers to quitting, and are around other smokers more often than survivors who had quit before or after their diagnosis, according to a ...

Melanoma mutation rewires cell metabolism

date 18 hours ago

A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme, researchers at Winship Cancer Institute of Emory University have discovered.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.