Protection against HSV-2 is added benefit of tenofovir

Protection against HSV-2 is added benefit of tenofovir

(HealthDay)—Tenofovir for HIV-1 preexposure prophylaxis (PrEP) provides the added benefit of protection against herpes simplex virus type 2 (HSV-2) acquisition, according to a study published in the July 1 issue of the Annals of Internal Medicine.

Connie Celum, M.D., M.P.H., from the University of Washington in Seattle, and colleagues conducted a study among and women in Kenya and Uganda who were seronegative for HIV-1 and HSV-2, but at high risk for HIV-1 acquisition due to having an infected partner. Participants were randomized to receive daily oral PrEP with antiretroviral tenofovir disoproxil fumarate (TDF) alone or in combination with emtricitabine (FTC-TDF).

The researchers found that 131 participants seroconverted to HSV-2 (79 of 1,041 assigned to tenofovir or FTC-TDF PrEP [HSV-2 incidence, 5.6 per 100 person-years] versus 52 of 481 assigned to [HSV-2 incidence, 7.7 per 100 person-years]). With daily oral PrEP, the hazard ratio (HR) for HSV-2 acquisition was 0.70 (P = 0.047) compared with placebo, with an absolute risk reduction of 2.1 per 100 person-years. The HR for PrEP was 0.67 (P = 0.038) among the 1,044 participants with HSV-2-infected partners, compared to placebo, with an absolute risk reduction of 3.1 per 100 person-years.

"Modest protection against HSV-2 is an added benefit of HIV-1 prevention with oral tenofovir-based PrEP," the authors write.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Drugs used to treat HIV also reduce risk of HIV infection

Jul 10, 2012

People at high risk of HIV infection can reduce their risk of acquiring the disease by taking antiretroviral drugs, according to Cochrane researchers. In an update of a systematic review first published in 2009, the researchers ...

Recommended for you

Preventing one case of HIV saves over $225K, study shows

Feb 27, 2015

How much money would be saved if one high-risk person was prevented from contracting HIV in the United States? A new study led by a researcher at Weill Cornell Medical College and published online Feb. 24 in Medical Care, answer ...

Research captures transient details of HIV genome packaging

Feb 27, 2015

Once HIV-1 has hijacked a host cell to make copies of its own RNA genome and viral proteins, it must assemble these components into new virus particles. The orchestration of this intricate assembly process falls to a viral ...

Could an HIV drug beat strep throat, flesh-eating bacteria?

Feb 25, 2015

With antibiotic resistance on the rise, scientists are looking for innovative ways to combat bacterial infections. The pathogen that causes conditions from strep throat to flesh-eating disease is among them, but scientists ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.