Antidepressants vary in their contribution to weight gain

Antidepressants vary in their contribution to weight gain

(HealthDay)—Antidepressants vary modestly in the likelihood of contributing to weight gain, according to a study published in the August issue of JAMA Psychiatry.

Sarah R. Blumenthal, from Massachusetts General Hospital in Boston, and colleagues identified 22,610 of a large New England health care system who began receiving an index antidepressant prescription and had available weight data in .

In models adjusting for sociodemographic and clinical features, the researchers observed a significantly decreased rate of weight gain in individuals treated with bupropion (P = 0.02), amitriptyline (P = 0.001), and nortriptyline (P < 0.001), compared with citalopram. Among individuals discontinuing treatment prior to 12 months, differences were smaller.

"Antidepressants differ modestly in their propensity to contribute to ," the authors write. "Short-term investigations may be insufficient to characterize and differentiate this risk."

Several authors disclosed financial ties to the pharmaceutical industry.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Inadequate weight gain in overweight moms tied to SGA

Aug 05, 2014

(HealthDay)—For overweight and obese women, inadequate weight gain is associated with increased risk of small for gestational age (SGA), according to a study published in the August issue of the America Jo ...

Recommended for you

Intervention program helps prevent high-school dropouts

10 hours ago

New research findings from a team of prevention scientists at Arizona State University demonstrates that a family-focused intervention program for middle-school Mexican American children leads to fewer drop-out rates and ...

Bilingualism over the lifespan

11 hours ago

It's a scene that plays out every day in Montreal. On the bus, in schools, in the office and at home, conversations weave seamlessly back and forth between French and English, or one of the many other languages represented ...

User comments