FDA clears Avastin for late-stage cervical cancer

August 15, 2014

The Food and Drug Administration has approved Genentech's Avastin for a new use against late-stage cervical cancer, the sixth indication for the blockbuster biotech drug.

The FDA approved the drug late Thursday for women with cervical cancer that is persistent, recurrent or has spread to other parts of the body. The disease is usually caused by the , which is spread through sexual contact and causes cells to become cancerous.

The National Cancer Institute estimates that over 12,300 U.S. women will be diagnosed with cervical cancer this year and 4,000 will die from the disease.

Avastin works by choking off blood vessels that help new cancer cells grow. The new use for is approved in combination with the chemotherapy drugs paclitaxel and cisplatin or in combination with paclitaxel and topotecan.

Avastin is already approved for various forms of colon cancer, lung cancer, glioblastoma and kidney cancer. The drug had global 2013 sales of $6.25 billion.

California-based Genentech is a unit of Swiss drugmaker Roche.

Related Stories

US revokes Roche's Avastin for breast cancer

November 18, 2011

US health officials on Friday revoked the authorization of Roche's Avastin for breast cancer treatment, saying it concluded the drug had "not been shown to be safe and effective for that use."

FDA approves genetic test for lung cancer drug

May 14, 2013

The Food and Drug Administration says it approved a genetic test from Roche to help doctors identify patients who can benefit from a lung cancer drug made by Genentech.

Recommended for you

Study reveals new insight into DNA repair

August 3, 2015

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy. New information published this week reveals more about why this occurs and how these breaks ...

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.