Uranium exposure tied to lupus

August 20, 2014
Uranium exposure tied to lupus

(HealthDay)—High uranium exposure is associated with systemic lupus erythematosus (SLE), according to a study published online Aug. 7 in Arthritis & Rheumatology.

Pai-Yue Lu-Fritts, M.D., from the University of Kentucky in Lexington, and colleagues analyzed data from community members with high prior exposure participating in the Fernald Community Cohort (FCC). American College of Rheumatology classification criteria, laboratory testing, and medical record review were used to identify SLE cases. Controls were matched (4:1) to each case based on age, race, and sex. Autoantibody screens were conducted.

The researchers found that in the FCC there were 4,187 individuals with background uranium exposure, 1,273 with moderate exposure, and 2,756 with higher exposure. Confirmed SLE was seen in 23 of 31 individuals with a lupus diagnostic code, and in two of 43 other individuals prescribed hydroxychloroquine. The female-to-male ratio was 5.25:1. Twelve of the 25 SLE cases were in the higher exposure group. SLE was associated with higher uranium exposure (odds ratio, 3.92; P = 0.031).

"Potential explanations for this relationship include possible autoimmune or estrogen effects of uranium, somatic mutation, epigenetic effects, or effects of some other unidentified accompanying exposure," the authors write.

Explore further: Uranium exposure linked to high lupus rates in community living near a former refinery

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Predictors of organ damage identified in patients with SLE

December 16, 2012

(HealthDay)—Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus (SLE), according to research published ...

Lupus ups risk of spontaneous subarachnoid hemorrhage

April 19, 2013

(HealthDay)—Patients with systemic lupus erythematosus (SLE) have an increased risk of spontaneous subarachnoid hemorrhage (SAH) and increased mortality after SAH, according to a study published in the April issue of Arthritis ...

Identifying targets of autoantibodies

November 25, 2013

Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems. The host factors that are targeted by autoantibodies produced by SLE patients ...

Recommended for you

New strategy for treating arthritis discovered

November 25, 2015

Arthritis patients could one day benefit from a novel form of medicine, according to researchers at Queen Mary University of London (QMUL). Their early study indicates that arthritic cartilage, previously thought to be impenetrable ...

Team finds gene that confirms existence of psoriatic arthritis

February 5, 2015

PsA is a common form of inflammatory form of arthritis causing pain and stiffness in joints and tendons that can lead to joint damage. Nearly all patients with PsA also have skin psoriasis and, in many cases, the skin disease ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.