Uranium exposure tied to lupus

Uranium exposure tied to lupus

(HealthDay)—High uranium exposure is associated with systemic lupus erythematosus (SLE), according to a study published online Aug. 7 in Arthritis & Rheumatology.

Pai-Yue Lu-Fritts, M.D., from the University of Kentucky in Lexington, and colleagues analyzed data from community members with high prior exposure participating in the Fernald Community Cohort (FCC). American College of Rheumatology classification criteria, laboratory testing, and medical record review were used to identify SLE cases. Controls were matched (4:1) to each case based on age, race, and sex. Autoantibody screens were conducted.

The researchers found that in the FCC there were 4,187 individuals with background uranium exposure, 1,273 with moderate exposure, and 2,756 with higher exposure. Confirmed SLE was seen in 23 of 31 individuals with a lupus diagnostic code, and in two of 43 other individuals prescribed hydroxychloroquine. The female-to-male ratio was 5.25:1. Twelve of the 25 SLE cases were in the higher exposure group. SLE was associated with higher uranium exposure (odds ratio, 3.92; P = 0.031).

"Potential explanations for this relationship include possible autoimmune or estrogen effects of uranium, somatic mutation, epigenetic effects, or effects of some other unidentified accompanying exposure," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Identifying targets of autoantibodies

date Nov 25, 2013

Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems. The host factors that are targeted by autoantibodies produced by SLE patients ...

Lupus ups risk of spontaneous subarachnoid hemorrhage

date Apr 19, 2013

(HealthDay)—Patients with systemic lupus erythematosus (SLE) have an increased risk of spontaneous subarachnoid hemorrhage (SAH) and increased mortality after SAH, according to a study published in the ...

Recommended for you

New test could predict arthritis drug failure in patients

date Jul 03, 2015

A study of 311 patients by The University of Manchester has found that it may be possible to predict early which rheumatoid arthritis (RA) patients will fail to respond to the biologic drugs given to treat them. These findings ...

About 8 percent of SLE patients have pulmonary HTN

date Jun 23, 2015

(HealthDay)—About 8 percent of patients with systemic lupus erythematosus (SLE) have pulmonary hypertension (PH), and serum uric acid (UA) has reasonable accuracy for predicting PH, according to a study ...

Early age of menopause linked to seropositivity in RA

date Jun 17, 2015

(HealthDay)—In women with early rheumatoid arthritis (RA), early age at menopause is associated with seropositivity, according to a study published in the May issue of Arthritis Care & Research.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.