Lupus ups risk of spontaneous subarachnoid hemorrhage

April 19, 2013
Lupus ups risk of spontaneous subarachnoid hemorrhage
Patients with systemic lupus erythematosus have an increased risk of spontaneous subarachnoid hemorrhage (SAH) and increased mortality after SAH, according to a study published in the April issue of Arthritis Care & Research.

(HealthDay)—Patients with systemic lupus erythematosus (SLE) have an increased risk of spontaneous subarachnoid hemorrhage (SAH) and increased mortality after SAH, according to a study published in the April issue of Arthritis Care & Research.

Yu-Sheng Chang, M.D., from Shuang Ho Hospital in Taipei, Taiwan, and colleagues conducted a nationwide, population-based study to assess the risk of SAH among patients with SLE. The incidence of SAH was compared in a cohort of 16,967 patients with SLE identified from the Taiwan National Health Insurance (NHI) database and 16,967 randomly selected age- and sex-matched individuals without SLE.

The researchers found that the incidence of SAH was significantly higher in the SLE cohort (incidence rate ratio, 4.84). Compared with all the non-SLE SAH patients identified from the NHI database, the mortality rate after SAH was significantly higher for patients with SLE, despite a younger age (60 versus 38.9 percent). Independent risk factors for new-onset SAH included age (hazard ratio [HR], 1.03); platelet transfusion (HR, 2.75); red blood cell transfusion (HR, 7.11); and a mean daily steroid dose greater than 10 mg prednisolone or equivalent (HR, 4.36).

"In conclusion, our study is the first to demonstrate a higher risk of SAH in SLE patients using a nationwide population data set," the authors write. "Elderly SLE patients and those with a higher mean daily steroid dose and a history of platelet or red blood cell transfusion had a higher risk of developing SAH."

Explore further: Quitting smoking cuts elevated subarachnoid hemorrhage risk

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Quitting smoking cuts elevated subarachnoid hemorrhage risk

September 5, 2012
(HealthDay)—Cigarette smoking increases the risk of subarachnoid hemorrhage (SAH) in a dose-responsive manner, and cessation correlates with a reduction in SAH risk, according to a study published online Aug. 30 in the ...

Predictors of organ damage identified in patients with SLE

December 16, 2012
(HealthDay)—Patient age, hypertension, and corticosteroid use are the most important predictors of the cumulative organ damage that occurs in patients with systemic lupus erythematosus (SLE), according to research published ...

Smoking, high blood pressure and cholesterol can be fatal for haemorrhage survivors, study finds

January 14, 2013
A Finnish study shows that patients who have experienced subarachnoid haemorrhage (SAH) have a highly increased risk of death due to a stroke or cerebral haemorrhage, and have double the mortality rate of the general population. ...

Study shows the HPV vaccine Gardasil doesn't increase disease activity in SLE patients

May 26, 2011
Results of a Chinese study showed that the HPV vaccine did not have significant effects on the number of disease flares or antibody measures in patients with inactive SLE receiving stable doses of medications after administration, ...

Teen vitamin D intake not related to adult RA or SLE risk

December 28, 2012
(HealthDay)—Dietary vitamin D intake during adolescence does not appear to be associated with the risk of adult-onset rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), according to research published in the ...

Recommended for you

Fluid in the knee holds clues for why osteoarthritis is more common in females

June 26, 2017
Researchers have more evidence that males and females are different, this time in the fluid that helps protect the cartilage in their knee joints.

Biologics before triple therapy not cost effective for rheumatoid arthritis

May 29, 2017
Stepping up to biologic therapy when methotrexate monotherapy fails offers minimal incremental benefit over using a combination of drugs known as triple therapy, yet incurs large costs for treating rheumatoid arthritis (RA). ...

Drug for refractory psoriatic arthritis shows promise in clinical trial

May 24, 2017
In a pivotal phase-3 clinical trial led by a Stanford University School of Medicine investigator, patients with psoriatic arthritis for whom standard-of-care pharmaceutical treatments have provided no lasting relief experienced ...

Cross-species links identified for osteoarthritis

May 17, 2017
New research from the University of Liverpool, published today in the journal npj Systems Biology and Applications, has identified 'cell messages' that could help identify the early stages of osteoarthritis (OA).

Osteoarthritis could be prevented with good diet and exercise

May 12, 2017
Osteoarthritis can potentially be prevented with a good diet and regular exercise, a new expert review published in the Nature Reviews Rheumatology reports.

Rodents with trouble walking reveal potential treatment approach for most common joint disease

May 11, 2017
Maintaining the supply of a molecule that helps to nourish cartilage prevented osteoarthritis in animal models of the disease, according to a report published in Nature Communications online May 11.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.