Agency for Science, Technology and Research (A*STAR), Singapore
The Agency for Science, Technology and Research (A*STAR) was formed in 2002 to promote science in Singapore. The A*STAR board is statutory and oversees A*STAR Graduate Academy, Joint Council Office, Biomedical Research Council, Science and Engineering Research Council, Exploit Technologies Private Limited, Corporate Planning and Administration Division. The objective is to promote scientific and technological discoveries, improvements and partner with private and public entities to achieve solutions for the betterment of Singapore and mankind.
#20-10 Connexis North Tower
Singapore 138632
First influenza vaccine brought to clinical testing
Singapore's Agency for Science, Technology and Research (A*STAR) and Switzerland's Cytos Biotechnology AG today announced that the first healthy volunteer has been dosed in a Phase 1 clinical trial with their ...
Medications
May 17, 2013 |
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Researchers develop first lab-on-chip for detection of multiple tropical infectious diseases
The Agency for Science, Technology and Research (A*STAR) and Veredus Laboratories, a leading supplier of innovative molecular diagnostic tools, announced the launch of VereTrop, the first biochip in the molecular diagnostics ...
Diseases, Conditions, Syndromes
Apr 25, 2013 |
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Computer program identifies rare mutations harbored within diverse populations of cancer cells and microorganisms
A tumor is not a uniform mass of identical cells. However, teasing apart genetic heterogeneity within a biopsied tumor can be difficult. Researchers often fail to tell the difference between a rare variant ...
Cancer
Apr 24, 2013 |
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Identification of specific genetic variants associated with common eye disorders could improve treatment and prevention
The eye is covered by a clear and protective layer called the cornea, and abnormal thickness of the cornea can result in eye disease. An international research team including Chiea Chuen Khor of the A*STAR ...
Genetics
Apr 24, 2013 |
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Understanding abnormal proteins in degenerative diseases
Amyloids, or fibrous aggregates of abnormally folded proteins, are a common feature in degenerative diseases such as Alzheimer's, diabetes and cancer. Amyloids occur naturally in the body, but despite decades ...
Medical research
Apr 22, 2013 |
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Insights into an abnormally edited RNA molecule may yield new weapons against a hard-to-kill cancer
Diagnosis of the brain cancer glioblastoma multiforme (GBM) is particularly bad news for patients due to limited available medical options and poor outcomes. Even treatments that can eliminate other malignancies, ...
Cancer
Apr 10, 2013 |
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Insights obtained by profiling immune response to repeat viral infections could assist vaccine design efforts
Patients who successfully beat infection with dengue virus remain vulnerable to reinfection by other dengue variants, and these secondary infections tend to be more severe. The antibodies arising from the ...
Immunology
Mar 27, 2013 |
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Artificial human livers engineered for drug testing and discovery
The liver is an important target organ for drug testing because all drugs pass through it for detoxification. This is a process whereby harmful substances are reduced or removed from the body. Drugs that cannot be detoxified ...
Medical research
Mar 15, 2013 |
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Protein implicated in lupus promotes disease progression by distinct mechanisms in different immune cells
Patients with systemic lupus erythematosus (SLE) come under attack by their immune system, producing 'autoantibodies' that inflict damage throughout the body. Antibodies normally target foreign proteins, ...
Immunology
Mar 13, 2013 |
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Cell metabolism: Muscle loss can be caused by mitochondrial degradation induced by protein Mul1
Muscle withering can occur as part of the progression of many diseases, including cancer and muscular dystrophy, as well as during the normal aging process. Cellular organelles known as mitochondria provide ...
Medical research
Mar 13, 2013 |
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Scientists discover 'switch' critical to wound healing
Patients with diseases such as diabetes suffer from painful wounds that take a long time to heal, making them more susceptible to infections that could even lead to amputations. A*STAR's discovery paves the way for therapeutics ...
Medical research
Mar 08, 2013 |
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LoFreq: Ultrafast detection of microbe and cancer cell mutations
Scientists at A*STAR's Genome Institute of Singapore (GIS) have developed a novel technique to precisely monitor and study the evolution of micro-organisms such as viruses and bacteria. This is an extremely important capability ...
Medical research
Mar 07, 2013 |
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Exposure to hepatitis B virus activates immunity in young people, suggesting benefits for earlier treatment
Infectious disease experts have long thought that children, teenagers and young adults who are chronically infected with the hepatitis B virus (HBV) lack the immune cells needed to fight this pathogen. As ...
Diseases, Conditions, Syndromes
Feb 27, 2013 |
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Fanning the flames of tumor growth: Enzyme responsible for protecting chromosome ends stimulates tumorigenesis
Chromosomes are capped by long, repetitive DNA sequences called telomeres. These caps prevent genomic damage by insulating against the steady shortening of DNA ends that naturally accompanies replication. ...
Cancer
Feb 27, 2013 |
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Unlimited source of human kidney cells: Applications include in vitro toxicology, disease models, regenerative medicine
Researchers at the Institute of Bioengineering and Nanotechnology (IBN) have successfully generated human kidney cells from human embryonic stem cells in vitro. Specifically, they produced the renal cells under artificial ...
Medical research
Feb 21, 2013 |
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