Broad Institute of MIT and Harvard
Amino acid consumption associated with how fast cancer cells divide
For almost a century, researchers have known that cancer cells have peculiar appetites, devouring glucose in ways that normal cells do not. But glucose uptake may tell only part of cancer's metabolic story. Researchers from ...
Cancer
May 24, 2012 |
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1,092 genomes and counting
Focusing on fine features in order to see "the big picture" seems almost counterintuitive, but that is exactly what is happening in the field of genomics. Researchers are sequencing human genomes, cataloging ...
Genetics
Nov 16, 2012 |
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ENCODE project: Researchers catalogue functional elements of the genome
Most of the DNA alterations that are tied to disease do not alter protein-coding genes, but rather the "switches" that control them. Characterizing these switches is one of many goals of the ENCODE project ...
Genetics
Sep 05, 2012 |
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Circuitry of cells involved in immunity, autoimmune diseases exposed
New work from the Broad Institute's Klarman Cell Observatory, Brigham and Women's Hospital, Harvard University, MIT, and Yale University expands the understanding of how one type of immune cell – known as a T helper 17 ...
Medical research
Mar 06, 2013 |
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Raising HDL not a sure route to countering heart disease
A new paper published online in The Lancet challenges the assumption that raising a person's HDL — the so-called "good cholesterol" — will necessarily lower the risk of a heart attack. The new research underscores the va ...
Cardiology
May 16, 2012 |
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New components of antiviral pathway discovered
Scientists studying how mammals detect microbes have discovered new components in a crucial pathway that allows immune cells to detect viral invaders. Their research not only deepens the understanding of antiviral responses, ...
Medical research
Dec 22, 2011 |
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First volume of the Cancer Cell Line Encyclopedia made public
The goal of cancer treatment is to match the right drug to the right target in the right patient. But before such "personalized" drugs can be developed, more knowledge is needed about specific genomic alterations in cancers ...
Cancer
Mar 28, 2012 |
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An ABSOLUTEly new view of the cancer genome
(Medical Xpress) -- Scientists hoping to unlock cancer’s secrets face a formidable challenge. Sophisticated research tools have allowed them to peer into the genomes of cancer cells and identify many ...
Cancer
May 04, 2012 |
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Chromatin marks the spot in search for disease pathways
In September 2012, the Encyclopedia of DNA Elements (ENCODE) Project Consortium, a multi-institution collaboration that included the Broad Institute, capped off nine years of research with a flurry of papers ...
Genetics
Jan 07, 2013 |
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Kidney disease mutations found in a genomic blind spot
(Medical Xpress)—Advances in DNA sequencing technology during the past decade have given scientists powerful tools to peer into the genomes of humans and other species. Despite the efficiency and sophistication ...
Genetics
Feb 11, 2013 |
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Following the footprints of positive selection
For decades, the human genome could only tell us what we already suspected about the evolution of certain traits. Researchers were able to trace the genetic origin stories of lactose tolerance (as opposed ...
Genetics
Feb 15, 2013 |
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Researchers move step closer to rapidly detecting resistant tuberculosis, other pathogens
For patients with infectious diseases like tuberculosis, timing is critical. Tuberculosis is one of the most common causes of death from a curable disease, and cases of drug-resistant tuberculosis are on the ...
Medical research
Apr 05, 2012 |
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Study reveals alternative pathway through which beta-catenin drives colon cancer
Colon cancer is one of the leading causes of cancer-related death in the United States. Risk factors for the disease are varied and include factors such as advanced age and diet, but most cases share something ...
Cancer
Dec 14, 2012 |
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