Cold Spring Harbor Laboratory
Storm of 'awakened' transposons may cause brain-cell pathologies in ALS, other illnesses
A team of neuroscientists and informatics experts at Cold Spring Harbor Laboratory (CSHL) reports important progress in an effort to understand the relationship between transposons – sequences of DNA that can jump around ...
Genetics
Sep 06, 2012 |
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ENCODE project: In massive genome analysis new data suggests 'gene' redefinition
Most people understand genes to be specific segments of DNA that determine traits or diseases that are inherited. Textbooks suggest that genes are copied ("transcribed") into RNA molecules, which are then used as templates ...
Genetics
Sep 05, 2012 |
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Archived Guthrie cards find a new purpose
Over the last 50 years, the spotting of newborn's blood onto filter paper for disease screening, called Guthrie cards, has become so routine that since 2000, more than 90% of newborns in the United States ...
Genetics
Aug 22, 2012 |
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Team introduces new method to closely model diseases caused by splicing defects
A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases – those with pathology caused by errors in the splicing of ...
Genetics
Aug 14, 2012 |
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Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size
Research published Aug. 1 by scientists at Cold Spring Harbor Laboratory (CSHL) links gene mutations found in some patients with Meier-Gorlin syndrome (MGS) with specific cellular dysfunctions that are thought to give rise ...
Genetics
Jul 31, 2012 |
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Differences between human twins at birth highlight importance of intrauterine environment
Your genes determine much about you, but environment can have a strong influence on your genes even before birth, with consequences that can last a lifetime. In a study published online in Genome Research, researchers have f ...
Genetics
Jul 15, 2012 |
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Gut microbes battle a common set of viruses shared by global populations
The human gut is home to a teeming ecosystem of microbes that is intimately involved in both human health and disease. But while the gut microbiota is interacting with our body, they are also under constant attack from viruses. ...
Genetics
Jun 25, 2012 |
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Neuroscientists reach major milestone in whole-brain circuit mapping project
Neuroscientists at Cold Spring Harbor Laboratory (CSHL) reached an important milestone today, publicly releasing the first installment out of 500 terabytes of data so far collected in their pathbreaking project to construct ...
Neuroscience
Jun 01, 2012 |
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RNA regulator of melanoma could be a new target for cancer therapy
Melanoma is the most deadly form of skin cancer, estimated by the National Cancer Institute to afflict more than 70,000 people in the United States annually and the incidence rate continues to rise. In a study published online ...
Cancer
May 10, 2012 |
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Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers
Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer ...
Cancer
May 07, 2012 |
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A striking link is found between the Fragile-X gene and mutations that cause autism
A team led by scientists at Cold Spring Harbor Laboratory (CSHL) publishes research today indicating a striking association between genes found disrupted in children with autism and genes that are targets of FMRP, the protein ...
Genetics
Apr 25, 2012 |
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Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
It should be possible to significantly improve the response of common cancers to existing "classical" chemotherapy drugs, say scientists at Cold Spring Harbor Laboratory (CSHL), by introducing agents that alter the interaction ...
Cancer
Apr 16, 2012 |
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'Druggable' protein complex identified as a therapeutic target in acute myeloid leukemia
Scientists at Cold Spring Harbor Laboratory have identified a candidate drug target for treating acute myeloid leukemia (AML), a white blood cell cancer that proliferates out of control in the bone marrow. The team, led by ...
Cancer
Apr 02, 2012 |
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Rats match humans in decision-making that involves combining different sensory cues: study
The next time you set a trap for that rat running around in your basement, here's something to consider: you are going up against an opponent whose ability to assess the situation and make decisions is statistically ...
Neuroscience
Mar 13, 2012 |
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Extended synaptic development may explain our cognitive edge over other primates
Over the first few years of life, human cognition continues to develop, soaking up information and experiences from the environment and far surpassing the abilities of even our nearest primate relatives. In a study published ...
Genetics
Feb 01, 2012 |
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