Cold Spring Harbor Laboratory
Gene mutation in autism found to cause hyperconnectivity in brain's hearing center
New research from Cold Spring Harbor Laboratory (CSHL) might help explain how a gene mutation found in some autistic individuals leads to difficulties in processing auditory cues and paying spatial attention to sound.
Neuroscience
Jan 31, 2012 |
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New automated imaging to greatly speed whole-brain mapping efforts
A new technology developed by neuroscientists at Cold Spring Harbor Laboratory (CSHL) transforms the way highly detailed anatomical images can be made of whole brains. Until now, means of obtaining such images ...
Medical research
Jan 15, 2012 |
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GABA signaling prunes back copious 'provisional' synapses during neural circuit assembly
Quite early in its development, the mammalian brain has all the raw materials on hand to forge complex neural networks. But forming the connections that make these intricate networks so exquisitely functional is a process ...
Neuroscience
Jan 03, 2012 |
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Gene fusion in lung cancer afflicting never-smokers may be target for therapy
Smoking is a well-known risk factor for lung cancer, but nearly 25% of all lung cancer patients have never smoked. In a study published online today in Genome Research, researchers have identified a previously unknown gene f ...
Genetics
Dec 22, 2011 |
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First comprehensive DNA study of mast cell leukemia uncovers clues that could improve therapy
Cancer researchers at Cold Spring Harbor Laboratory (CSHL) have carried out the first comprehensive study of the changes seen in the DNA of a patient with mast cell leukemia (MCL), an extremely aggressive subtype of acute ...
Cancer
Dec 16, 2011 |
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New book on HIV from Cold Spring Harbor Laboratory Press
The worldwide AIDS epidemic makes research on HIV, the disease processes it induces, and potential HIV therapies among the most critical in biomedical science. Furthermore, the basic biology of HIV infections ...
HIV & AIDS
Dec 15, 2011 |
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Unexpected signaling role for foul-smelling hydrogen sulfide in cell response to protein misfolding
Something rotten never smelled so sweet. This is what members of a team of scientists at Cold Spring Harbor Laboratory (CSHL) are telling one another as they discuss a new finding they did not expect to make. They have discovered ...
Medical research
Dec 13, 2011 |
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Pharmacogenomics study finds rare gene variants critical for personalized drug treatment
The use of genetic tests to predict a patient's response to drugs is increasingly important in the development of personalized medicine. But genetic tests often only look for the most common gene variants. In a pharmacogenomics ...
Genetics
Dec 05, 2011 |
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Study reveals details of alternative splicing circuitry that promotes cancer's Warburg effect
Cancer cells maintain their life-style of extremely rapid growth and proliferation thanks to an enzyme called PK-M2 (pyruvate kinase M2) that alters the cells' ability to metabolize glucose – a phenomenon known as the ...
Medical research
Nov 02, 2011 |
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X-linked mental retardation protein is found to mediate synaptic plasticity in hippocampus
Scientists at Cold Spring Harbor Laboratory (CSHL) have solved part of a puzzle concerning the relationship between changes in the strength of synapses – the tiny gaps across which nerve cells in the brain communicate ...
Neuroscience
Oct 19, 2011 |
4.7 / 5 (3) |
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Possible link between bacterium, colon cancer found
For the first time, a specific microorganism has been found to be associated with human colorectal cancer. In two studies published online today in Genome Research, independent research teams have identified Fusobacterium in col ...
Cancer
Oct 17, 2011 |
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Long-term correction of severe spinal muscular atrophy by antisense therapy
A new study from Cold Spring Harbor Laboratory (CSHL) reports surprising results that suggest that the devastating neuromuscular disease, spinal muscular atrophy (SMA), might not exclusively affect the motor neurons in the ...
Medical research
Oct 05, 2011 |
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New evidence for genetic basis of autism found
Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that one of the most common genetic alterations in autism -- deletion of a 27-gene cluster on chromosome 16 -- causes autism-like features. ...
Genetics
Oct 03, 2011 |
4.3 / 5 (9) |
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Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity
The work of a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes ...
Medical research
Sep 29, 2011 |
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Team creates genetic 'GPS' system to comprehensively locate and track inhibitory nerve cells
A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has succeeded in creating what amounts to a GPS system for locating and tracking a vital class of brain cells that until now has eluded comprehensive identification, ...
Neuroscience
Sep 21, 2011 |
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