Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)—a form of early-onset dementia that is similar to Alzheimer's disease. ...
Oct 8, 2012
0
0
Each year, 9 months of dreams and anticipation shared by millions of parents-to-be turn to despair and fright when learning their child is born with a birth defect; an often-devastating event affecting one out of 20 children ...
Jul 24, 2019
0
473
It's surprisingly hard to tell when a brain cell is dead. Neurons that appear inactive and fragmented under the microscope can persist in a kind of life-or-death limbo for days, and some suddenly begin signaling again after ...
Dec 8, 2021
0
112
A team of scientists at the Gladstone Institutes has identified a new way to make latent HIV reveal itself, which could help overcome one of the biggest obstacles to finding a cure for HIV infection. They discovered that ...
Jun 5, 2014
0
0
CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have co-opted the CRISPR-Cas9 ...
Feb 3, 2022
0
89
A scientist at the Gladstone Institutes has identified how the lack of a brain chemical known as dopamine can rewire the interaction between two groups of brain cells and lead to symptoms of Parkinson's disease. This discovery ...
Sep 8, 2011
1
0
Researchers from the Gladstone Institutes have used human cells to discover how blood flow in the heart protects against the hardening of valves in cardiovascular disease. What's more, they've identified a potential way to ...
Mar 12, 2015
0
13
Scientists at the Gladstone Institutes have discovered an unusual regulator of body weight and the metabolic syndrome: a molecular mechanism more commonly associated with brain cells. Lowering levels of P75 neurotrophin receptor ...
Jan 12, 2016
0
190
Normally, the blood protein fibrin does not enter the brain. But in several neurological disorders, the blood-brain barrier—which keeps large molecules in the blood from entering the brain—becomes abnormally permeable, ...
Oct 15, 2018
1
33
Scientists at the Gladstone Institutes have invented a new way to read and interpret the human genome. The computational method, called TargetFinder, can predict where non-coding DNA—the DNA that does not code for proteins—interacts ...
Apr 4, 2016
0
135
