Journal of Clinical Investigation

Oncology & Cancer

HPV leaves its mark in oropharyngeal squamous cell carcinoma

Oropharyngeal squamous cell carcinoma (OPSCC) is a form of cancer that affects the cells lining the middle part of the throat, including the soft palate, the base of the tongue, the tonsils, and the pharynx.

Oncology & Cancer

Histone deacetylase 6 inhibition enhances oncolytic viral therapy

Gliomas are extremely aggressive brain tumors that are resistant to standard cancer therapeutics. Oncolytic viral (OV) therapy, which uses engineered viruses to infect and target tumor cells for destruction by the immune ...

Genetics

Insulin resistance linked to a human gene variant

Insulin resistance is a risk factor for developing both type 2 diabetes and cardiovascular disease. Almost one third of the U.S. population has some degree of insulin resistance, though it is undiagnosed in many of these ...

HIV & AIDS

Could probiotics help HIV patients?

Antiretroviral (ARV) drugs are the first line therapy for patients with HIV; however, ARV-treated, HIV-infected individuals still have a higher mortality rate than uninfected individuals. During the course of infection, HIV ...

Medical research

A gut feeling about neural stem cells

Proper function of the digestive system requires coordinated contraction of the muscle in the wall of the intestinal tract, regulated by the enteric nervous system. Damage or loss of these neurons can result in intestinal ...

Oncology & Cancer

Biomarkers predict time to ovarian cancer recurrence

Ovarian cancer often remains undetected until it is at an advanced stage. Despite positive responses to initial treatment, many patients are at risk of tumor recurrence. A multitude of genetic markers have been implicated ...

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