Journal of Clinical Investigation
Small proteins in the cornea protect against bacterial infection
When it comes to germ-busting power, the eyes have it, according to a discovery by University of California, Berkeley, researchers that could lead to new, inexpensive antimicrobial drugs.
Medical research
Sep 24, 2012 |
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Diabetes drug tested in Parkinson's disease patients
Parkinson's disease (PD) is a degenerative neurological disorder marked by a progressive loss of motor control. Despite intensive research, there are currently no approved therapies that have been demonstrated to alter the ...
Parkinson's & Movement disorders
May 20, 2013 |
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A potential biomarker for pregnancy-associated heart disease?
Peripartum cardiomyopathy (PPCM) is a deterioration in cardiac function that occurs in pregnant women during the last month or in the months following their pregnancy. This disorder can occur in women with no prior history ...
Diseases, Conditions, Syndromes
Apr 24, 2013 |
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Protecting against aging at the molecular level
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental ...
Medical research
Apr 08, 2013 |
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Pulmonary fibrosis: Between a ROCK and a hard place
Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to transmit oxygen to the blood stream, ...
Medical research
Feb 22, 2013 |
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How to mend a broken heart: Advances in parthenogenic stem cells
Parthenogenesis is a form of asexual reproduction during which unfertilized eggs begin to develop as if they had been fertilized. It occurs naturally in many plants and a few invertebrate (some bees, scorpions, parasitic ...
Medical research
Feb 22, 2013 |
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A gut feeling about neural stem cells
Proper function of the digestive system requires coordinated contraction of the muscle in the wall of the intestinal tract, regulated by the enteric nervous system. Damage or loss of these neurons can result in intestinal ...
Medical research
Feb 01, 2013 |
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Prostate cancer cells thrive on stress
Not surprisingly, a cancer diagnosis creates stress. And patients with prostate cancer show higher levels of anxiety compared to other cancer patients.
Cancer
Jan 25, 2013 |
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Stem cell-derived dopaminergic neurons rescue motor defects in Parkinsonian monkeys
Parkinson's disease is a degenerative disorder of the central nervous system that is characterized by tremors, rigidity, slowness of movement, and difficulty walking. It is caused by loss of the neurons that produce the neurotransmitter ...
Parkinson's & Movement disorders
Dec 03, 2012 |
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Seizures linked to surgery drugs can be prevented by anesthetics, study finds (Update)
Two drugs commonly given during cardiac surgery can lead to convulsive seizures, but anesthetics can help cut the risk, according to new research from the Faculty of Medicine at the University of Toronto.
Neuroscience
Nov 26, 2012 |
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A new target in acute myeloid leukemia
Acute myeloid leukemia, a common leukemia in adults, is characterized by aberrant proliferation of cancerous bone marrow cells. Activating mutations in a protein receptor known as FLT3 receptor are among the most prevalent ...
Cancer
Jul 16, 2012 |
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Improving obesity-induced insulin sensitivity
In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into ...
Overweight and Obesity
Jun 01, 2012 |
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Gene therapy can correct forms of severe combined immunodeficiency
Severe combined immunodeficiency is defect in the immune system that results in a loss of the adaptive immune cells known as B cells and T cells. Mutations in several different genes can lead to the development of severe ...
Immunology
May 24, 2012 |
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Gene replacement in pigs ameliorates cystic fibrosis-associated intestinal obstruction
Cystic fibrosis (CF) is caused by mutations in CFTR and is characterized by dysfunction of the lungs, liver, pancreas, and intestines. Approximately 15% of babies with CF are born with an obstruction of the small intestine ...
Diseases, Conditions, Syndromes
May 08, 2013 |
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Alzheimer's disease is associated with removal of the synaptic protein ADAM10
Alzheimer's disease is characterized by the accumulation of neurotoxic β-amyloid peptide (A-beta). ADAM10, a protein that resides in the neural synapses, has previously been shown to prevent the formation of A-beta.
Alzheimer's disease & dementia
May 08, 2013 |
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