Sanford-Burnham Medical Research Institute
Chemical reaction keeps stroke-damaged brain from repairing itself
Nitric oxide, a gaseous molecule produced in the brain, can damage neurons. When the brain produces too much nitric oxide, it contributes to the severity and progression of stroke and neurodegenerative diseases ...
Medical research
Feb 04, 2013 |
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Patients' skin cells transformed into heart cells to create 'disease in a dish'
Researchers use skin cells from patients with an inherited heart condition to recreate the adult-onset disease in a laboratory dish—producing the first maturation-based disease model for testing new therapies.
Medical research
Jan 27, 2013 |
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Transplanted neural stem cells treat ALS in mouse model
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is untreatable and fatal. Nerve cells in the spinal cord die, eventually taking away a person's ability to move or even breathe. A ...
Medical research
Dec 19, 2012 |
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'Junk DNA' drives embryonic development
An embryo is an amazing thing. From just one initial cell, an entire living, breathing body emerges, full of working cells and organs. It comes as no surprise that embryonic development is a very carefully ...
Genetics
Dec 03, 2012 |
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Discovery of new heart failure trigger could change the way cardiovascular drugs are made
In their quest to treat cardiovascular disease, researchers and pharmaceutical companies have long been interested in developing new medicines that activate a heart protein called APJ. But researchers at Sanford-Burnham ...
Cardiology
Jul 18, 2012 |
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Researchers identify target to prevent hardening of arteries
The hardening of arteries is a hallmark of atherosclerosis, an often deadly disease in which plaques, excessive connective tissue, and other changes build up inside vessel walls and squeeze off the flow of ...
Cardiology
May 16, 2013 |
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A cautionary tale on genome-sequencing diagnostics for rare diseases
Children born with rare, inherited conditions known as Congenital Disorders of Glycosylation, or CDG, have mutations in one of the many enzymes the body uses to decorate its proteins and cells with sugars. Properly diagnosing ...
Genetics
May 10, 2013 |
3 / 5 (1) |
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Differences between 'marathon mice' and 'couch potato mice' reveal key to muscle fitness
Researchers discovered that small pieces of genetic material called microRNAs link the two defining characteristics of fit muscles: the ability to burn sugar and fat and the ability to switch between slow- ...
Medical research
May 08, 2013 |
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White blood cell enzyme contributes to inflammation and obesity
Many recent studies have suggested that obesity is associated with chronic inflammation in fat tissues. Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered that an ...
Inflammatory disorders
Apr 02, 2013 |
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Newly identified tumor suppressor provides therapeutic target for prostate cancer
Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have identified how an enzyme called PKCζ suppresses prostate tumor formation. The finding, which also describes a molecular chain ...
Cancer
Apr 01, 2013 |
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Researchers unravel molecular roots of Down syndrome
Sanford-Burnham researchers discover that the extra chromosome inherited in Down syndrome impairs learning and memory because it leads to low levels of SNX27 protein in the brain.
Medical research
Mar 24, 2013 |
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How some prostate tumors resist treatment—and how it might be fixed
Hormonal therapies can help control advanced prostate cancer for a time. However, for most men, at some point their prostate cancer eventually stops responding to further hormonal treatment. This stage of ...
Cancer
Mar 18, 2013 |
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Molecule's structure reveals new therapeutic opportunities for rare diabetes
Researchers at Sanford-Burnham Medical Research Institute have determined the complete three-dimensional structure of a protein called HNF-4α. HNF-4α controls gene expression in the liver and pancreas, ...
Medical research
Mar 13, 2013 |
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Diabetic fruit flies support buzz about dietary sugar dangers
Regularly consuming sucrose—the type of sugar found in many sweetened beverages—increases a person's risk of heart disease. In a study published January 10 in the journal PLOS Genetics, researchers at San ...
Genetics
Jan 17, 2013 |
4 / 5 (3) |
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How belly fat differs from thigh fat—and why it matters
Men tend to store fat in the abdominal area, but don't usually have much in the way of hips or thighs. Women, on the other hand, are more often pear-shaped—storing more fat on their hips and thighs than in the belly. Why ...
Medical research
Jan 11, 2013 |
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