News tagged with animal model
(Medical Xpress)—Researchers at UC Davis have shown how the innate immune system distinguishes between dangerous pathogens and friendly microbes. Like burglars entering a house, hostile bacteria give themselves away by ...
Immunology Apr 01, 2013 | 4.3 / 5 (3) | 0 |
Scientists at the University of Pittsburgh School of Medicine have discovered a new biological pathway of innate immunity that ramps up inflammation and then identified agents that can block it, leading to increased survival ...
Immunology Mar 31, 2013 | 4.8 / 5 (4) | 1 |
New study validates longevity pathway: Findings identify universal mechanism for activating anti-aging pathway
A new study demonstrates what researchers consider conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity in animal models. What's more, the researchers ...
Medical research Mar 07, 2013 | 4.8 / 5 (20) | 6 |
Sorting out stroking sensations: Biologists find individual neurons in the skin that react to massage
The skin is a human being's largest sensory organ, helping to distinguish between a pleasant contact, like a caress, and a negative sensation, like a pinch or a burn. Previous studies have shown that these ...
Neuroscience Jan 30, 2013 | 5 / 5 (1) | 0 |
Nearly half of the 700,000 cancer patients who undergo surgical removal of a primary tumor each year suffer a recurrence of their disease at some point, and many of those patients will eventually die from their disease. The ...
Cancer Dec 27, 2012 | not rated yet | 1 |
Research from the Perelman School of Medicine at the University of Pennsylvania and Massachusetts General Hospital (MGH) reveals that sons of male rats exposed to cocaine are resistant to the rewarding effects of the drug, ...
Neuroscience Dec 16, 2012 | 5 / 5 (1) | 0 |
(Medical Xpress)—Hot flushes are not "in the head," but new research suggests they may start there. A UA research team has identified a region in the brain that may trigger the uncomfortable surges of heat ...
Medical research Dec 11, 2012 | not rated yet | 0 |
Measles vaccine given with painless and easy-to-administer microneedle patches can immunize against measles at least as well as vaccine given with conventional hypodermic needles, according to research done ...
Medications Nov 27, 2012 | 5 / 5 (2) | 0 |
Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson's disease from binding together and killing the brain's neurons.
Alzheimer's disease & dementia Nov 15, 2012 | 4.5 / 5 (6) | 3 |
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown that a single protein plays an oversized role in intellectual and behavioral development. The scientists found that mutations in a single ...
Genetics Nov 08, 2012 | 4.5 / 5 (4) | 0 |
A drug commonly used in treating breast cancer could have far wider benefits, offering a new way of preventing cancers spreading through the body, according to a University of Leeds-led study.
Cancer Nov 06, 2012 | 4.8 / 5 (4) | 0 |
Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)—a form of early-onset dementia that is similar to Alzheimer's disease. ...
Neuroscience Oct 08, 2012 | not rated yet | 0 |
Potential new class of drugs protects nerve cells in models of Parkinson's disease, amyotrophic lateral sclerosis
Researchers at the University of Iowa and the University of Texas Southwestern Medical Center in Dallas, have identified a new class of small molecules that block nerve cell death in animal models of Parkinson's disease and ...
Medical research Oct 01, 2012 | 5 / 5 (1) | 0 |
A team of neuroscientists and chemists from the U.S. and China today publish research suggesting that a class of currently used anti-cancer drugs as well as several previously untested synthetic compounds show effectiveness ...
Alzheimer's disease & dementia Sep 24, 2012 | 4.8 / 5 (4) | 0 |
(Medical Xpress)—A University of Arizona professor is overseeing the manufacture of an experimental drug that could help reduce brain damage after a stroke.
Medical research Sep 21, 2012 | 5 / 5 (1) | 1 |
An animal model is a non-human animal that has a disease or injury that is similar to a human condition. These test conditions are often termed as animal models of disease. The use of animal models allows researchers to investigate disease states in ways which would be inaccessible in a human patient, performing procedures on the non-human animal that imply a level of harm that would not be considered ethical to inflict on a human.
In order to serve as a useful model, a modeled disease must be similar in etiology (mechanism of cause) and function to the human equivalent. Animal models are used to learn more about a disease, its diagnosis and its treatment. For instance, behavioral analogues of anxiety or pain in laboratory animals can be used to screen and test new drugs for the treatment of these conditions in humans. A 2000 study found that animal models predicted human toxicity in 71% of cases, with 63% for nonrodents alone and 43% for rodents alone.
Animal models of disease can be spontaneous (naturally occurring in animals), or be induced by physical, chemical or biological means. For example,
The increase in knowledge of the genomes of non-human primates and other mammals that are genetically close to humans is allowing the production of genetically engineered animal tissues, organs and even animal species which express human diseases, providing a more robust model of human diseases in an animal model.
Animal models observed in the sciences of psychology and sociology are often termed animal models of behavior.
In quantitative genetics, the term animal model is used to refer to statistical models in which phenotypic variance is compartmentalised into environmental, genetic and sometimes maternal effects. Such animal models are also known as "mixed models".
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