News tagged with autoimmunity

Related topics: autoimmune diseases

Researchers solve multiple sclerosis puzzle

Evidence has long suggested multiple sclerosis (MS) is an autoimmune disease, but researchers have been puzzled because they found the same T cells that attack the myelin sheathing around nerve cells in MS ...

May 14, 2015
popularity 499 comments 0

Infant antibiotic use linked to adult diseases

A new study led by researchers at the University of Minnesota has found a three-way link among antibiotic use in infants, changes in the gut bacteria, and disease later in life. The imbalances in gut microbes, called dysbiosis, ...

May 13, 2015
popularity 82 comments 6

Worms and germs lead to better immune function

A growing body of evidence in the medical community holds that greater diversity of bacteria and even worms in the digestive tract offers protection against a variety of allergic and autoimmune problems.

Apr 08, 2015
popularity 142 comments 1

Autoimmunity

Autoimmunity is the failure of an organism to recognize its own constituent parts as self, which allows an immune response against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. Autoimmunity is often caused by a lack of germ development of a target body and as such the immune response acts against its own cells and tissues. Prominent examples include Coeliac disease, diabetes mellitus type 1 (IDDM), systemic lupus erythematosus (SLE), Sjögren's syndrome, Churg-Strauss Syndrome, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, rheumatoid arthritis (RA), lupus and allergies. Autoimmune diseases are very often treated with steroids.

The misconception that an individual's immune system is totally incapable of recognizing self antigens is not new. Paul Ehrlich, at the beginning of the twentieth century, proposed the concept of horror autotoxicus, wherein a 'normal' body does not mount an immune response against its own tissues. Thus, any autoimmune response was perceived to be abnormal and postulated to be connected with human disease. Now, it is accepted that autoimmune responses are an integral part of vertebrate immune systems (sometimes termed 'natural autoimmunity'), normally prevented from causing disease by the phenomenon of immunological tolerance to self-antigens. Autoimmunity should not be confused with alloimmunity.

This text uses material from Wikipedia licensed under CC BY-SA