News tagged with autoimmunity

Related topics: autoimmune diseases

Sensitive balance in the immune system

Apoptosis is used by cells that are changed by disease or are simply not needed any longer to eliminate themselves before they become a hazard to the body—on a cellular level, death is part of life. Disruption ...

Apr 11, 2014
popularity 4 / 5 (1) | comments 0

Can antibiotics cause autoimmunity?

The code for every gene includes a message at the end of it that signals the translation machinery to stop. Some diseases, such as cystic fibrosis and Duchenne muscular dystrophy, can result from mutations that insert this ...

Mar 31, 2014
popularity 3.5 / 5 (2) | comments 1

B-cells aggravate autoimmune diseases

Scientists in Freiburg may have discovered a fundamental aggravating factor in autoimmune diseases. If B-lymphocytes lack the protein PTP1B, the cells will become hyperactive for stimulatory signals and can ...

Mar 04, 2014
popularity 5 / 5 (2) | comments 0

New target for psoriasis treatment discovered

Researchers at King's College London have identified a new gene (PIM1), which could be an effective target for innovative treatments and therapies for the human autoimmune disease, psoriasis.

Feb 12, 2014
popularity 4.4 / 5 (12) | comments 1 | with audio podcast

Slowing down the immune system when in overdrive

Many people suffer from chronic inflammation because their immune systems overreact to 'self' tissue. Sydney scientists believe that a small molecule known as Interleukin 21 is a promising therapeutic target in such cases.

Feb 10, 2014
popularity 5 / 5 (3) | comments 0 | with audio podcast

Imaging autoimmune diabetes

Researchers at Lund University have managed to develop a technique whereby they can study the inflammatory process that takes place in the pancreas during the natural development of type 1 diabetes, allowing for real time ...

Jan 29, 2014
popularity not rated yet | comments 0

Autoimmunity

Autoimmunity is the failure of an organism to recognize its own constituent parts as self, which allows an immune response against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease. Autoimmunity is often caused by a lack of germ development of a target body and as such the immune response acts against its own cells and tissues. Prominent examples include Coeliac disease, diabetes mellitus type 1 (IDDM), systemic lupus erythematosus (SLE), Sjögren's syndrome, Churg-Strauss Syndrome, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, rheumatoid arthritis (RA), lupus and allergies. Autoimmune diseases are very often treated with steroids.

The misconception that an individual's immune system is totally incapable of recognizing self antigens is not new. Paul Ehrlich, at the beginning of the twentieth century, proposed the concept of horror autotoxicus, wherein a 'normal' body does not mount an immune response against its own tissues. Thus, any autoimmune response was perceived to be abnormal and postulated to be connected with human disease. Now, it is accepted that autoimmune responses are an integral part of vertebrate immune systems (sometimes termed 'natural autoimmunity'), normally prevented from causing disease by the phenomenon of immunological tolerance to self-antigens. Autoimmunity should not be confused with alloimmunity.

This text uses material from Wikipedia licensed under CC BY-SA