Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease (SCD) and beta thalassemia. These two common life-threatening anemias afflict millions of individuals across the globe.
Jun 29, 2023
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Scientists have discovered that the cells of early human embryos are often unable to repair damage to their DNA. The researchers say that this has important implications for the proposed use of gene editing techniques to ...
Jun 26, 2023
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By studying the effects of DNA variants between people, researchers can gain insights into the genetics of diseases. It allows them to tailor medical treatment to a person's genetic makeup.
May 3, 2023
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CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes. However, this process is associated with side effects including unwanted mutations and toxicity. Therefore, ...
Apr 10, 2023
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Second only to the notorious TP53 gene, the genes for assemblages known as mSWI/SNF protein complexes are the most frequently mutated entities in cancer cells. Made up of 10 to 15 subunits, the complexes are built from the ...
Apr 10, 2023
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Scientists at St. Jude Children's Research Hospital comprehensively characterized oncogenic fusions in pediatric cancer, providing proof-of-principle for genetic engineering-based therapies.
Apr 5, 2023
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A new research paper, titled "VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer," was published in Genes & Cancer on March ...
Mar 24, 2023
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A new approach that delivers a "one-two punch" to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania. The findings, published ...
Mar 15, 2023
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A team of researchers at the University of Texas Southwestern Medical Center has found that it is possible in mice to protect the heart from ischemia-reperfusion using the CRISPR-Cas9 gene editing system. In their paper published ...
A research team led by scientists from the University of Veterinary Medicine Vienna (Vetmeduni) has taken an important step toward a better understanding of certain difficult-to-treat blood cancers. The researchers have identified ...
Jan 19, 2023
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