Calcium may cut risk for precancerous colon lesions in some people
(HealthDay)—Consuming higher amounts of calcium may lower the likelihood of precancerous colon and rectal lesions in people who are at increased risk due to variations in two genes, a new study suggests.
Cancer
Apr 10, 2013 |
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Two-drug combo more effective in treating sarcomas, study shows
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have found that when given together, a two-drug combination acts synergistically in test animals modeled with sarcoma tumors. They report ...
Cancer
Apr 09, 2013 |
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Excess estrogen in pregnancy can silence BRCA1 in daughters, increasing breast cancer risk
Excess estrogen levels during pregnancy can disable, in their daughters, a powerful breast cancer tumor suppressor gene, say researchers at Georgetown Lombardi Comprehensive Cancer Center. They found the DNA repair gene BRCA1 ...
Cancer
Apr 09, 2013 |
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Researchers identify gene variations that predict chemotherapy side effects
Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found. The study identified gene variations that can predispose people ...
Cancer
Apr 09, 2013 |
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First genetic factor in prostate cancer prognosis identified
Patients with prostate cancer and hereditary mutations in the BRCA2 gene have a worse prognosis and lower survival rates than do the rest of the patients with the disease. This is the main conclusion to come out of a study ...
Cancer
Apr 09, 2013 |
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Six2 homeoprotein allows breast cancer cells to detach and metastasize
In results presented at the AACR Annual Meeting 2013, researchers from the University of Colorado Cancer Center show that the Six2 homeoprotein, while not involved in primary tumor growth, allows cells to detach from substrate ...
Cancer
Apr 09, 2013 |
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K9 osteosarcoma samples identify drivers of metastasis in pediatric bone cancer
Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000 canine patients develop the ...
Cancer
Apr 09, 2013 |
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Little molecule makes big difference in bladder cancer metastasis
In order to kill, bladder cancer must metastasize, most commonly to the lung – what are the differences between bladder cancers that do and do not make this deadly transition? Research presented by the Director of the University ...
Cancer
Apr 09, 2013 |
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Misregulated genes common to tobacco-related cancers offer potential new prognostic tool
Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes. ...
Cancer
Apr 09, 2013 |
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New genetic link found between normal fetal growth and cancer
Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and ...
Genetics
Apr 09, 2013 |
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Study finds key to calling back-up help when tumor-fighter p53 goes down
Tumor suppression, the family business of the sibling genes p53, p63 and p73, is undermined from within by the split personalities of p63 and p73, which each produce protein forms that not only block the work of the other ...
Cancer
Apr 08, 2013 |
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Exploring lincRNA's role in breast cancer
Once considered part of the "junk" of our genome, much of the DNA between protein-coding genes is now known to be transcribed. New findings by scientists at Fox Chase Cancer Center have identified several dozen transcripts ...
Cancer
Apr 08, 2013 |
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Nearly half of breast cancer patients at risk of having BRCA mutations not sent for genetic testing
Only 53 percent of newly diagnosed breast cancer patients who were at high risk of carrying a BRCA 1 or BRCA 2 mutation – based on age, diagnosis, and family history of breast or ovarian cancer – reported that their doctors ...
Cancer
Apr 08, 2013 |
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Preclinical study indicates potential for novel inhibitor to overcome drug resistance induced by RAF, MEK inhibitors
A new class of investigational medicines may help to treat patients with cancers driven by mutations in genes such as BRAF or KRAS/NRAS, including those patients who have become resistant to therapies that target BRAF directly, ...
Cancer
Apr 08, 2013 |
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More accurate markers identified for detecting response to epigenetic drugs for myelodysplastic syndromes
Researchers have identified and validated two DNA methylation markers that could help physicians to more accurately determine a patient's response to epigenetic drugs for treatment of myelodysplastic syndromes (MDS), according ...
Cancer
Apr 08, 2013 |
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