Study shows key enzyme missing from aggressive form of breast cancer
A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain—providing insight ...
Cancer
Feb 28, 2013 |
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Study identifies growth factor essential to the most common malignant pediatric brain tumor
A multi-institutional team led by Massachusetts General Hospital (MGH) researchers has identified a molecular pathway that appears to be essential for the growth and spread of medulloblastoma, the most common ...
Cancer
Feb 28, 2013 |
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Biomarker may identify neuroblastomas with sensitivity to BET bromodomain inhibitors
Neuroblastoma, the most common malignant tumor of early childhood, is frequently associated with the presence of MYCN amplification, a genetic biomarker associated with poor prognosis. Researchers have determined that tumors ...
Cancer
Feb 21, 2013 |
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Researchers find potential new therapeutic target for treating non-small cell lung cancer
Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune ...
Cancer
Feb 15, 2013 |
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Researchers discover biological diversity in triple-negative breast cancer
Triple-negative breast cancers are more biologically diverse than previously believed and classification should be expanded to reflect this heterogeneity, according to University of North Carolina researchers.
Cancer
Feb 13, 2013 |
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Researchers find new clue to clinical trial failures of MMP cancer therapies
Proposed cancer therapeutic drugs based on blocking the catalytic activities of matrix metalloproteinases (MMPs), which profoundly remodel the environment surrounding a breast cell, have performed poorly ...
Cancer
Feb 12, 2013 |
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Researchers identify new strategy for interfering with potent cancer-causing gene
Acute myeloid leukemia (AML) is an aggressive blood cancer that is currently incurable in 70% of patients. In a bold effort, CSHL scientists are among those identifying and characterizing the molecular mechanisms responsible ...
Cancer
Feb 11, 2013 |
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High doses of saw palmetto don't impact serum PSA
(HealthDay)—Compared with placebo, saw palmetto, even at a dose as high as 960 mg, does not affect serum prostate-specific antigen (PSA) levels in men with lower urinary tract symptoms, according to research ...
Cancer
Feb 08, 2013 |
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New strategy prevents rheumatoid arthritis in mice
Dana-Farber Cancer Institute scientists have demonstrated a new strategy for treating autoimmune disease that successfully blocked the development of rheumatoid arthritis in a mouse model. They say it holds promise for improved ...
Arthritis & Rheumatism
Feb 08, 2013 |
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A step towards better understanding of pancreatic cancer
(Medical Xpress)—An international team of scientists has observed that the well-studied protein Sirtuin-1, known for helping cells live longer, also appears to play an important role in pancreatic cancer.
Cancer
Feb 05, 2013 |
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Engineered oncolytic herpes virus inhibits ovarian and breast cancer metastases
A genetically reprogrammed Herpes simplex virus (HSV) can cure metastatic diffusion of human cancer cells in the abdomen of laboratory mice, according to a new study published January 31 in the Open Access journal PLOS Pa ...
Cancer
Jan 31, 2013 |
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Transition in cell type parallels treatment response, disease progression in breast cancer
A process that normally occurs in developing embryos – the changing of one basic cell type into another – has also been suspected of playing a role in cancer metastasis. Now a study from Massachusetts General Hospital ...
Cancer
Jan 31, 2013 |
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New target for treating wide spectrum of cancers
(Medical Xpress)—UC Irvine biologists, chemists and computer scientists have identified an elusive pocket on the surface of the p53 protein that can be targeted by cancer-fighting drugs. The finding heralds a new treatment ...
Cancer
Jan 31, 2013 |
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Common genetic alteration found in head and neck cancers may not be key to effective treatment
Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway, data recently published in Cancer Research, a journal of the American Association for Cancer Research, indicated that d ...
Cancer
Jan 29, 2013 |
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Study provides new drug target for Her-2 related breast cancer
Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, details exactly how the Her2 cancer gene ...
Cancer
Jan 22, 2013 |
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