Immunology

Study pinpoints key pathway in inflammation and aging

In patients with colitis, a serious condition affecting the gut, the immune system turns against the body's own microbes, causing inflammation. To combat this inflammation, scientists have focused in on a chemical signal ...

Immunology

How the tuberculosis vaccine may protect against other diseases

The tuberculosis vaccine is well known to help protect against other infectious diseases, as well as cancer, but the exact mechanisms have not been clear. A study published December 6 in Cell Reports now shows that the broad-spectrum ...

Inflammatory disorders

Natural metabolite can suppress inflammation

An international group of scientists from the U.S., Canada, Germany and Russia has revealed a naturally occurring organic compound that can suppress the pro-inflammatory activity of macrophages. The compound, itaconate, is ...

Oncology & Cancer

New cancer vaccine approach directly targets dendritic cells

Celldex Therapeutics announced today that final data from its Phase 1 study of CDX-1401 in solid tumors, including long-term patient follow-up, have been published in Science Translational Medicine. The data demonstrate robust ...

Immunology

Sensitive balance in the immune system

Apoptosis is used by cells that are changed by disease or are simply not needed any longer to eliminate themselves before they become a hazard to the body—on a cellular level, death is part of life. Disruption of this process ...

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