Medical research

How chromosomes keep their loose ends loose

We take it for granted that our chromosomes won't stick together, yet this kind of cellular disaster would happen constantly were it not for a protein called TRF2. Now, scientists at The Scripps Research Institute (TSRI) ...

Medical research

A model-free way to characterize polymodal ion channel gating

Two studies in The Journal of General Physiology (JGP) help pave the way for a "shortcut" model-free approach to studying activation of "polymodal" ion channels—channels that open in response to multiple stimuli.

Medical research

Scientists find mechanism that triggers immune responses to DNA

(Medical Xpress)—Free-floating pieces of DNA in a cell's watery interior can mean bad things: invading viruses, bacteria, or parasites, ruptured cellular membranes, or disease. Genetic material is meant to be contained ...

Medical research

Geometry plays a role in GPCR transmembrane signaling

A recent study in The Journal of General Physiology characterizes the movement of rhodopsin, a GPCR and member of a large family of transmembrane receptors responsible for many cellular responses and involved in many human ...

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