Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a molecule that inhibits the action of estrogen. This female hormone plays a key role in the growth, maintenance and repair of reproductive ...
Medical research
May 09, 2012 |
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Prdm16: A novel gene important for craniofacial development
In the United States, a baby is born with a facial cleft every hour, of every day of the year! Such birth defects result from both gene mutations and environmental insults. PRDM16 is a transcription factor originally described ...
Medical research
May 02, 2012 |
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High-strength silk scaffolds improve bone repair
Biomedical engineers at Tufts University's School of Engineering have demonstrated the first all-polymeric bone scaffold material that is fully biodegradable and capable of providing significant mechanical support during ...
Medical research
Apr 30, 2012 |
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Genetic research develops tools for studying diseases, improving regenerative treatment
Research from a Kansas State University professor may make it easier to recover after spinal cord injury or to study neurological disorders.
Genetics
Mar 19, 2012 |
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BRG1 mutations confer resistance to hormones in lung cancer
Retinoic acid (vitamin A) and steroids are hormones found in our body that protect against oxidative stress, reduce inflammation and are involved in cellular differentiation processes. One of the characteristics of tumours ...
Cancer
Mar 15, 2012 |
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Scientists identify crucial cell and signaling pathway in placental blood stem cell niche
(Medical Xpress) -- UCLA stem-cell researchers have identified a certain type of cell and a signaling pathway in the placental niche that play a key role in stopping blood stem cells from differentiating into mature blood ...
Medical research
Mar 01, 2012 |
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Study: Muscle regeneration may provide ideal environment for rhabdomyosarcoma
Inflammation, cell division and cell differentiation that occur during skeletal muscle regeneration may provide an ideal environment for the highly malignant tumor, rhabdomyosarcoma to arise. These are the findings from a ...
Cancer
Feb 22, 2012 |
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Three studies find IDH enzyme mutations may alter activity leading to growth of cancer tumors
(Medical Xpress) -- Three research teams have published papers in Nature, that together offer evidence suggesting that isocitrate dehydrogenase (IDH) enzyme mutations may play a role in altering activity that could have a ...
Medical research
Feb 16, 2012 |
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Protein that functions in normal breast may also contribute to breast cancer metastasis
The trefoil factor 3 (TFF3) protein protects and maintains the integrity of the epithelial surface in the normal breast. New research has found that while TFF3 protein expression is higher in well-differentiated low grade ...
Cancer
Feb 16, 2012 |
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How poor maternal diet can increase risk of diabetes -- new mechanism discovered
Researchers have shown one way in which poor nutrition in the womb can put a person at greater risk of developing type 2 diabetes and other age-related diseases in later life. This finding could lead to new ways of identifying ...
Medical research
Jan 06, 2012 |
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Exploring the mechanism behind the differentiation of immune cells
Ichiro Taniuchi at the RIKEN Research Center for Allergy and Immunology, Japan, is carrying out research to understand the mysteries of organism evolution by investigating the mechanism responsible for the ...
Medical research
Dec 19, 2011 |
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Long non-coding RNA prevents the death of maturing red blood cells
A long non-coding RNA (lncRNA) regulates programmed cell death during one of the final stages of red blood cell differentiation, according to Whitehead Institute researchers. This is the first time a lncRNA has been found ...
Genetics
Dec 07, 2011 |
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A brighter future for infertility treatment: study
(Medical Xpress) -- Male infertility could soon have a boost through new treatments at a sub-DNA 'epigenetic' level, according to researchers from The Australian National University.
Genetics
Dec 05, 2011 |
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3-D long-term bone marrow culture to analyze stromal cell biological function
Stromal cells, as distinct from hematopoietic cells, are an essential component of the bone marrow microenvironment and are necessary for the long-term maintenance of hematopoietic stem cells (HSCs) in vitro. Previous studies ...
Medical research
Nov 02, 2011 |
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How major signaling pathways are wired to our genome gives new insight into disease processes
Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each ...
Medical research
Oct 27, 2011 |
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