A new statistical tool developed by researchers at the University of Chicago improves the ability to find genetic variants that cause disease. The tool, described in a new paper published January 26, 2024, in Nature Genetics, ...
Jan 26, 2024
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A new research paper titled "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes" has been published in Aging.
Dec 19, 2023
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Colorectal cancer (CRC) presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10–15% of CRC cases, indicates a different clinical trajectory than microsatellite ...
Dec 15, 2023
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A new study by Claudia Kutter's research group at the Department of Microbiology, Tumor and Cell Biology (MTC) has identified potential pitfalls in the use of the gene editing technique CRISPR-Cas9, a gene scissors that is ...
Nov 21, 2023
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Men with a particular genetic subtype of the steroid biosynthesis enzyme HSD3B1 may exhibit resistance to combined radiation and hormone therapy for prostate cancer, according to new Cleveland Clinic-led research published ...
Nov 20, 2023
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Many disorders are caused by genetic variants; to make matters worse, the genetic origin of most disorders remains unknown. Now, in a study recently published in the Journal of Clinical Immunology, researchers have shed light ...
Nov 15, 2023
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Our DNA is not indestructible. Throughout the course of our lives, DNA can break in response to natural and environmental factors. Thankfully, our bodies have dedicated enzymes and pathways which can glue our broken DNA back ...
Nov 15, 2023
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Researchers have identified genetic tests that predict which cancer patients may benefit from the drugs in combination with chemotherapy.
Nov 6, 2023
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Metabolites called nucleotides are the building blocks of DNA and can impact cancer's sensitivity or resistance to chemotherapy and radiation in brain cancer. Findings from researchers at the University of Michigan Health ...
Nov 2, 2023
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A surprising mechanism that makes some cancers treatment-resistant has been discovered by Weill Cornell Medicine and NewYork-Presbyterian investigators. The mechanism, which involves the shuttling of messenger RNAs (mRNAs) ...
Nov 2, 2023
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