Canada launches first gene therapy trial for Fabry disease
Researchers in Calgary have launched the first gene therapy clinical trial in the world for Fabry disease, a rare inherited enzyme deficiency that can shorten the lifespan of people who have it by as much as 40 years.
Diseases, Conditions, Syndromes
Jan 24, 2013 |
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Blocking digestive enzymes may reverse shock, stop multiorgan failure
New research from the University of California, San Diego published in the Jan. 23 issue of Science Translational Medicine moves researchers closer to understanding and developing treatments for shock, sepsis ...
Medical research
Jan 23, 2013 |
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Circadian rhythms can be modified for potential treatment of disorders
(Medical Xpress)—UC Irvine-led studies have revealed the cellular mechanism by which circadian rhythms – also known as the body clock – modify energy metabolism and also have identified novel compounds that control ...
Cardiology
Jan 22, 2013 |
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Enzyme replacement therapy shows promising results in X-linked myotubular myopathy
A collaborative research team including a Medical College of Wisconsin (MCW) pediatric neuropathologist successfully mitigated some of the effects of a muscular disease by using a new targeted enzyme replacement therapy strategy ...
Genetics
Jan 22, 2013 |
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Researchers identify enzyme involved in deadly brain tumors
One of the most common types of brain tumors in adults, glioblastoma multiforme, is one of the most devastating. Even with recent advances in surgery, radiation and chemotherapy, the aggressive and invasive tumors become ...
Cancer
Jan 17, 2013 |
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Novel technique reveals dynamics of telomere DNA structure
Biomedical researchers studying aging and cancer are intensely interested in telomeres, the protective caps on the ends of chromosomes. In a new study, scientists at UC Santa Cruz used a novel technique to reveal structural ...
Medical research
Jan 17, 2013 |
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Lack of key enzyme in the metabolism of folic acid leads to birth defects
Researchers at The University of Texas at Austin have discovered that the lack of a critical enzyme in the folic acid metabolic pathway leads to neural tube birth defects in developing embryos.
Medical research
Jan 17, 2013 |
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Enzyme CaM kinase II relaxes muscle cells: Researchers find overactive enzyme in failing hearts
A certain enzyme, the CaM kinase II, keeps the cardiac muscle flexible. By transferring phosphate groups to the giant protein titin, it relaxes the muscle cells. This is reported by researchers led by Prof. ...
Cardiology
Jan 17, 2013 |
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Researchers attack HIV's final defenses before drug-resistant mutations emerge
Scientists who study HIV are facing a troubling consequence of their own success. They created drugs that can now give infected patients almost normal life expectancy. However, those same drugs will eventually ...
HIV & AIDS
Jan 16, 2013 |
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Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
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Scientists uncover potential drug target to block cell death in Parkinson's disease
Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, Amyotrophic Lateral Sclerosis and Parkinson's disease. Now, scientists from the Florida campus of ...
Parkinson's & Movement disorders
Jan 10, 2013 |
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Modified antibodies trigger immune response, point to novel vaccine design strategies
In an approach with the potential to aid therapeutic vaccine development, Whitehead Institute scientists have shown that enzymatically modified antibodies can be used to generate highly targeted, potent responses from cells ...
Medical research
Jan 07, 2013 |
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New compound overcomes drug-resistant Staph infection in mice
Researchers have discovered a new compound that restores the health of mice infected with methicillin-resistant Staphylococcus aureus (MRSA), an otherwise dangerous bacterial infection. The new compound targets ...
Medical research
Jan 07, 2013 |
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Chromatin marks the spot in search for disease pathways
In September 2012, the Encyclopedia of DNA Elements (ENCODE) Project Consortium, a multi-institution collaboration that included the Broad Institute, capped off nine years of research with a flurry of papers ...
Genetics
Jan 07, 2013 |
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Fulyzaq approved for ART-related diarrhea in HIV/AIDS
(HealthDay)—The first medication to treat diarrhea in people with HIV/AIDS who take antiretroviral drugs has been approved by the U.S. Food and Drug Administration.
Medications
Jan 03, 2013 |
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