Medications

New drug target to treat pain from visceral organs

An approved drug for chronic constipation also relieves the pain associated with that condition. New research by Scott Waldman, MD, Ph.D., chair of pharmacology, physiology and cancer biology at Jefferson, demonstrates that ...

Genetics

Scientists identify gene that controls scarring in damaged hearts

Scientists at Duke-NUS Medical School have identified a gene that controls the behavior of a specific type of cardiac macrophage responsible for excessive scarring during the early phases of common heart diseases or cardiomyopathies. ...

Immunology

How the thymus trains T cells to fight infections

T cells are a special class of white blood cells that patrol the body and attack infected or foreign tissue. They learn to distinguish friendly proteins from dangerous ones in an organ called the thymus. However, when T cells ...

Diseases, Conditions, Syndromes

Gut molecules may affect fattiness of liver

Sphingolipids—molecules ubiquitous throughout the human body, named after the Egyptian Sphinx for their complexity when scientists discovered them nearly 150 years ago—are not necessarily household conversation topics.

Oncology & Cancer

Boosting the immune response against cancer

T cells are usually good at eliminating diseased cells, but they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, and how ...

Neuroscience

Study explains how light could activate neurons

Human brains have an average of 86 billion neurons. These nerve cells are interconnected at junctions known as synapses, and some neurons have as many as 10,000 such synapses. A key to understanding brain function is to have ...

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