Genetics may explain severe flu in Chinese people
A genetic variant commonly found in Chinese people may help explain why some got seriously ill with swine flu, a discovery scientists say could help pinpoint why flu viruses hit some populations particularly ...
Diseases, Conditions, Syndromes
Jan 29, 2013 |
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Researchers generate mutant mouse model useful in treatment of neuromuscular diseases
Researchers at the University of Granada have produced for the first time in the world mice lacking the coenzyme Q10, a rare mitochondrial disease prevailingly affecting children. The researchers needed three ...
Genetics
Jan 29, 2013 |
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Study finds new genetic defects in high-risk childhood leukemia subtypes with chromosomal loss
Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes.
Genetics
Jan 20, 2013 |
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Ability to metabolize tamoxifen affects breast cancer outcomes, study confirms
For nearly a decade, breast cancer researchers studying the hormone therapy tamoxifen have been divided as to whether genetic differences in a liver enzyme affect the drug's effectiveness and the likelihood breast cancer ...
Cancer
Dec 27, 2012 |
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Preventing prostate cancer through androgen deprivation may have harmful effects
Mice deficient in PTEN in the prostate developed stable precancers. Androgen deprivation promoted progression to invasive prostate cancer. Patients with PTEN-deficient prostate precancers may not benefit from androgen deprivation ...
Cancer
Dec 20, 2012 |
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Study unmasks regulator of healthy life span
A new series of studies in mouse models by Mayo Clinic researchers uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and ...
Medical research
Dec 17, 2012 |
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Two new genetic mutations associated with Cowden syndrome
Cleveland Clinic researchers from the Lerner Research Institute have uncovered two new genes associated with Cowden syndrome (CS) according to a new study, published today in the online version of the American Journal of ...
Genetics
Dec 13, 2012 |
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Diverse genetic alterations found in triple-negative breast cancers after neoadjuvant chemotherapy
Many different genetic alterations were detected in tumor cells left behind after patients with triple-negative breast cancer were treated with chemotherapy prior to surgery (neoadjuvant chemotherapy), according to data presented ...
Cancer
Dec 07, 2012 |
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Neuroblastoma patients with ARID1A and ARID1B mutations have more aggressive disease
In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia (CHOP) found that patients with changes in two genes, ARID1A ...
Genetics
Dec 02, 2012 |
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Kidney tumors have a mind of their own
New research has found there are several different ways that kidney tumours can achieve the same result – namely, grow.
Cancer
Nov 21, 2012 |
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Identification of mutations common to half of all liver cancers provides leads for new therapeutics
Liver cancer is the sixth most common cancer worldwide and the third leading cause of cancer-associated deaths. Yet even for such a frequent and deadly disease, the pathogenesis of this cancer remains obscure. ...
Cancer
Nov 16, 2012 |
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Genome sequencing of Burkitt Lymphoma reveals unique mutation
In the first broad genetic landscape mapped of a Burkitt lymphoma tumor, scientists at Duke Medicine and their collaborators identified 70 mutations, including several that had not previously been associated with cancer and ...
Genetics
Nov 12, 2012 |
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Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
New insight into the aggressive behavior of certain adult B-acute lymphoblastic leukemias has provided researchers with a potential new prognostic biomarker and a promising new therapeutic target.
Cancer
Oct 29, 2012 |
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Researchers identify novel genes that may drive rare, aggressive form of uterine cancer
Researchers have identified several genes that are linked to one of the most lethal forms of uterine cancer, serous endometrial cancer. The researchers describe how three of the genes found in the study are ...
Cancer
Oct 28, 2012 |
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Of mice and men
The use of carefully chosen animal models often underlies crucial medical advances. A perfect example is provided by the recent demonstration that a known drug, imatinib, can be used to treat a rare but ...
Cancer
Oct 15, 2012 |
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