Stanford researchers have learned how basal cell carcinoma evades drug treatment without mutating. The researchers found possible drug targets that may allow for more personalized treatment of this common skin cancer.
Feb 6, 2018
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St. Jude Children's Research Hospital scientists have discovered a promising target for precision medicines to block a mechanism that drives several cancers, including about 30 percent of cases of the brain tumor called medulloblastoma. ...
Nov 2, 2017
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Liver cancer has the second-highest worldwide cancer mortality, and yet there are limited therapeutic options to manage the disease. To learn more about the genetic causes of this cancer, and to identify potential new therapeutic ...
Jun 16, 2017
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An experimental drug originally identified in a National Cancer Institute library of chemical compounds as a potential therapy for brain and basal cell cancers improves the symptoms of mice with a form of the debilitating ...
Sep 30, 2015
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The whimsically named sonic hedgehog gene, best known for controlling embryonic development, also maintains the normal physiological state and repair process of an adult healthy lung, if damaged, according to new research ...
Oct 5, 2015
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Researchers from Charité - Universitätsmedizin Berlin have discovered that the survival of cancer stem cells is dependent on the Hedgehog signaling pathway. Targeting this pathway had previously shown no effect on the growth ...
Jan 22, 2018
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Erxi Wu, assistant professor of pharmaceutical sciences, co-wrote the review article, “The paracrine Sonic Hedgehog signaling derived from tumor epithelial cells: A key regulator in the pancreatic tumor microenvironment,” ...
Feb 17, 2012
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Hailed as a major step forward in the effort to develop targeted cancer therapies, a recently approved drug for the most common type of skin cancer has been a mixed blessing for patients. Although the initial response is ...
Feb 27, 2013
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Scientists have identified the key molecular pathway leading to depression, revealing potential new targets for drug discovery, according to research led by King's College London's Institute of Psychiatry. The study, published ...
Dec 6, 2012
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Johns Hopkins investigators are testing a way to use drugs that target a cholesterol pathway to enhance the cancer-killing potential of standard chemotherapy drugs. Their tests, in mouse models of pancreatic cancer, may yield ...
Apr 3, 2012
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