News tagged with knockout mice
Research opens up possibility of therapies to restore blood-brain barrier
(Medical Xpress)—Research led by Queen Mary, University of London, has opened up the possibility that drug therapies may one day be able to restore the integrity of the blood-brain barrier, potentially ...
Medical research
Jan 02, 2013 |
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Study finds key protein for firing up central nervous system inflammation
Scientists have identified an influential link in a chain of events that leads to autoimmune inflammation of the central nervous system in a mouse model of multiple sclerosis (MS).
Medical research
May 02, 2013 |
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Intestinal protein may have role in ADHD, other neurological disorders
A biochemical pathway long associated with diarrhea and intestinal function may provide a new therapeutic target for treating ADHD (Attention Deficit Hyperactivity Disorder) other neuropsychiatric disorders, according to ...
Attention deficit disorders
Aug 11, 2011 |
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Researchers discover molecular link between circadian clock disturbances and inflammatory diseases
Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic ...
Medical research
Aug 01, 2012 |
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Gene gives clues to self-injurious behavior in rare disorder
In humans, inherited mutations in a gene called HPRT1 lead to very specific self-destructive behavior. Boys with Lesch-Nyhan disease experience uncontrollable urges to bite their fingers, slam their arms into doorways and ...
Medical research
Jul 27, 2011 |
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Study could aid development of new drugs to treat gout
Findings from a Loyola University Chicago Stritch School of Medicine study could lead to the development of new drugs to treat gout. The study, led by Liang Qiao, MD, and his colleagues and collaborators, was published March ...
Immunology
Mar 19, 2013 |
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Researchers identify and block protein that interferes with appetite-suppressing hormone
Ever since the appetite-regulation hormone called leptin was discovered in 1994, scientists have sought to understand the mechanisms that control its action. It was known that leptin was made by fat cells, reduced appetite ...
Medical research
Apr 17, 2013 |
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Researchers decode a kind of trigger switch for the conversion of fat cells
For a long time, scientists have dreamed of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten ...
Medical research
Apr 23, 2013 |
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Liver fat gets a wake-up call that maintains blood sugar levels
A Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that m ...
Medical research
May 06, 2012 |
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Abcc10 may be effective in extending the effectiveness of anticancer drugs
Today's anticancer drugs often work wonders against malignancies, but sometimes tumors become resistant to the effects of such drugs, and treatment fails. Medical researchers would like to find ways of counteracting such ...
Cancer
May 16, 2011 |
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New resource to unlock the role of microRNAs
A new resource to define the roles of microRNAs is announced today in Nature Biotechnology. The resource, called mirKO, gives researchers access to tools to investigate the biological role and significance for human health ...
Medical research
Aug 07, 2011 |
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Scientists link dietary DHA to male fertility
Who knew that male fertility depends on sperm-cell architecture? A University of Illinois study reports that a certain omega-3 fatty acid is necessary to construct the arch that turns a round, immature sperm cell into a pointy-headed ...
Health
Jan 09, 2012 |
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Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
Women who have eggs that cannot mature will not become pregnant, and they cannot be helped by in vitro fertilization (IVF). Now researchers at the University of Gothenburg, Sweden, have identified a molecule called Cdk1 that ...
Genetics
Mar 05, 2012 |
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Lactation protein suppresses tumors and metastasis in breast cancer, scientists discover
A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton ...
Cancer
Oct 24, 2012 |
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Telmisartan reverses insulin resistance in mice
(HealthDay)—Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ (PPAR-δ) gene is present, ...
Diabetes
Jan 03, 2013 |
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