News tagged with ligands
Engineered antibody demonstrated safety, efficacy in wide range of advanced tumors
(Medical Xpress)—The engineered antibody MPDL3280A, which targets a protein called programmed death-ligand 1 (PD-L1), was safe and effective for several cancers, according to phase I study results presented at the AACR ...
Cancer
Apr 10, 2013 |
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Monocyte migrations
LMU researchers led by Christian Weber have, for the first time, elucidated how cells that promote the development of atherosclerosis find their way to the blood vessel wall, where they stimulate the formation of obstructive ...
Medical research
Feb 19, 2013 |
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Why cells stick: Phenomenon extends longevity of bonds between cells
Research carried out by scientists at the Georgia Institute of Technology and The University of Manchester has revealed new insights into how cells stick to each other and to other bodily structures, an essential function ...
Medical research
Feb 14, 2013 |
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Ruling the airways: Notch controls bronchial cell fates and distributions
Nestled deep within the body, the epithelial lining of the respiratory system is nonetheless seriously exposed. Its direct contact with environmental air necessitates protective mechanisms that both seal ...
Medical research
Jan 22, 2013 |
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Study identifies potential new pathway for drug development
A newly found understanding of receptor signaling may have revealed a better way to design drugs. A study from Nationwide Children's Hospital suggests that a newly identified group of proteins, alpha arrestins, may play a ...
Medical research
Dec 10, 2012 |
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Study identifies how zebrafish regrow their brains
(Medical Xpress)—An international team of scientists has discovered the mechanism by which zebrafish can re-grow brain neurons after they have suffered traumatic brain injury, and that this mechanism is ...
Medical research
Nov 09, 2012 |
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Lexatumumab tolerated for pediatric solid tumors
(HealthDay)—Lexatumumab, an agonistic, full human monoclonal antibody against tumor necrosis factor-related apoptosis-inducing ligand receptor 2, is well tolerated and may lessen certain clinical symptoms ...
Cancer
Oct 16, 2012 |
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Target for obesity drugs comes into focus
(Medical Xpress)—Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and body weight, interacts with a key receptor in the brain.
Medical research
Oct 11, 2012 |
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Scientists provide detailed view of brain protein structure: Results may help improve drugs for neurological disorders
Researchers have published the first highly detailed description of how neurotensin, a neuropeptide hormone which modulates nerve cell activity in the brain, interacts with its receptor. Their results suggest that neuropeptide ...
Medical research
Oct 10, 2012 |
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Jump-starting cheaper cancer vaccines
Dendritic cells (DCs)—workhorses of the immune system—derived from human embryonic stem cells (hESCs) may provide an economical way of generating off-the-shelf therapeutic vaccines against cancers, according ...
Immunology
Sep 26, 2012 |
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Denosumab reduces burden of giant-cell tumor of the bone
Treatment with denosumab, a drug targeted against a protein that helps promote bone destruction, decreased the number of tumor giant cells in patients with giant-cell tumor of the bone, and increased new bone formation, according ...
Cancer
Sep 21, 2012 |
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Metastatic 'switch' could lead to cancer therapies
(Medical Xpress)—What kills cancer patients often isn't the primary tumor; it's when the tumor metastasizes—or spreads the cancer to other areas of the body.
Cancer
Sep 11, 2012 |
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Cancer therapy that boosts immune system ready for wider testing
Two clinical trials led by Johns Hopkins Kimmel Cancer Center researchers in collaboration with other medical centers, testing experimental drugs aimed at restoring the immune system's ability to spot and attack cancer, have ...
Cancer
Jun 02, 2012 |
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Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved
Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells.
Cancer
May 30, 2012 |
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Mechanism ID'd for benefit of stem cells in autoimmunity
(HealthDay) -- Bone marrow mesenchymal stem cells (BMMSCs) activate a mechanism involving coupling of FAS/FAS ligand to induce T cell apoptosis and immune tolerance, according to an experimental study published ...
Medical research
May 02, 2012 |
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Ligand
In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from covalent to ionic. Furthermore, the metal-ligand bond order can range from one to three. Ligands are viewed as Lewis bases, although rare cases are known involving Lewis acidic "ligands."
Metal and metalloids are bound to ligands in virtually all circumstances, although gaseous "naked" metal ions can be generated in high vacuum. Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry, homogeneous catalysis, and environmental chemistry.
Ligands are classified in many ways: their charge, their size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity). The size of a ligand is indicated by its cone angle.
For more information about Ligand, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
