News tagged with ligands
(Medical Xpress)—An international team of scientists has discovered the mechanism by which zebrafish can re-grow brain neurons after they have suffered traumatic brain injury, and that this mechanism is ...
Medical research Nov 09, 2012 | 4.9 / 5 (9) | 3 |
Scientists provide detailed view of brain protein structure: Results may help improve drugs for neurological disorders
Researchers have published the first highly detailed description of how neurotensin, a neuropeptide hormone which modulates nerve cell activity in the brain, interacts with its receptor. Their results suggest that neuropeptide ...
Medical research Oct 10, 2012 | 5 / 5 (1) | 0 |
Two clinical trials led by Johns Hopkins Kimmel Cancer Center researchers in collaboration with other medical centers, testing experimental drugs aimed at restoring the immune system's ability to spot and attack cancer, have ...
Cancer Jun 02, 2012 | 4.6 / 5 (7) | 0 |
(Medical Xpress)—Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and body weight, interacts with a key receptor in the brain.
Medical research Oct 11, 2012 | 5 / 5 (2) | 0 |
Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells.
Cancer May 30, 2012 | not rated yet | 0 |
Could engineered fatty particles help prevent AIDS? Liposomes block HIV infection in early tests; could be a cost-effective preventive for developing countries
HIV & AIDS Sep 19, 2011 | 5 / 5 (1) | 1 |
(Medical Xpress)—What kills cancer patients often isn't the primary tumor; it's when the tumor metastasizes—or spreads the cancer to other areas of the body.
Cancer Sep 11, 2012 | not rated yet | 0 |
A new report in Biological Psychiatry suggests that deficits in endocannabinoid function may contribute to anorexia nervosa and bulimia. Endocannabinoids are substances made by the brain that affect brain function and ch ...
Psychology & Psychiatry Oct 31, 2011 | 5 / 5 (1) | 0
The internet is awash with stories of how silver can be used to treat cancer. Now, lab tests have shown that it is as effective as the leading chemotherapy drug - and may have fewer side-effects.
Cancer Feb 02, 2012 | 5 / 5 (3) | 0 |
(Medical Xpress)—The engineered antibody MPDL3280A, which targets a protein called programmed death-ligand 1 (PD-L1), was safe and effective for several cancers, according to phase I study results presented at the AACR ...
Cancer Apr 10, 2013 | 4 / 5 (1) | 0
The benefits of breast milk are well known, but why breastfeeding protects against various forms of cancer remains a mystery. A new study in the Journal of Human Lactation found high levels of cancer-fighting TNF-related apopto ...
Health Apr 23, 2012 | not rated yet | 0
Research carried out by scientists at the Georgia Institute of Technology and The University of Manchester has revealed new insights into how cells stick to each other and to other bodily structures, an essential function ...
Medical research Feb 14, 2013 | 5 / 5 (1) | 0 |
Macrophages playing an important role in the immune system eat and fight against pathogens and foreign substances in the very beginning of infection. In this condition, macrophages produce reactive oxygen species for sterilization. ...
Immunology Apr 09, 2012 | not rated yet | 0
Glioblastoma, a lethal brain cancer, is one of the most resistant to available therapies and patients typically live approximately 15 months.
Cancer Jan 24, 2012 | 5 / 5 (1) | 0
Dendritic cells (DCs)—workhorses of the immune system—derived from human embryonic stem cells (hESCs) may provide an economical way of generating off-the-shelf therapeutic vaccines against cancers, according ...
Immunology Sep 26, 2012 | not rated yet | 0
In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from covalent to ionic. Furthermore, the metal-ligand bond order can range from one to three. Ligands are viewed as Lewis bases, although rare cases are known involving Lewis acidic "ligands."
Metal and metalloids are bound to ligands in virtually all circumstances, although gaseous "naked" metal ions can be generated in high vacuum. Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry, homogeneous catalysis, and environmental chemistry.
Ligands are classified in many ways: their charge, their size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity). The size of a ligand is indicated by its cone angle.
For more information about Ligand, read the full article at
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