News tagged with ligands
Study identifies how zebrafish regrow their brains
(Medical Xpress)—An international team of scientists has discovered the mechanism by which zebrafish can re-grow brain neurons after they have suffered traumatic brain injury, and that this mechanism is ...
Medical research
Nov 09, 2012 |
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Scientists provide detailed view of brain protein structure: Results may help improve drugs for neurological disorders
Researchers have published the first highly detailed description of how neurotensin, a neuropeptide hormone which modulates nerve cell activity in the brain, interacts with its receptor. Their results suggest that neuropeptide ...
Medical research
Oct 10, 2012 |
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Cancer therapy that boosts immune system ready for wider testing
Two clinical trials led by Johns Hopkins Kimmel Cancer Center researchers in collaboration with other medical centers, testing experimental drugs aimed at restoring the immune system's ability to spot and attack cancer, have ...
Cancer
Jun 02, 2012 |
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Target for obesity drugs comes into focus
(Medical Xpress)—Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and body weight, interacts with a key receptor in the brain.
Medical research
Oct 11, 2012 |
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Breast stem-cell research: Receptor teamwork is required and a new pathway may be involved
Breast-cancer researchers at the University of Wisconsin-Madison have found that two related receptors in a robust signaling pathway must work together as a team to maintain normal activity in mammary stem cells.
Cancer
May 30, 2012 |
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Could engineered fatty particles help prevent AIDS?
Could engineered fatty particles help prevent AIDS? Liposomes block HIV infection in early tests; could be a cost-effective preventive for developing countries
HIV & AIDS
Sep 19, 2011 |
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Metastatic 'switch' could lead to cancer therapies
(Medical Xpress)—What kills cancer patients often isn't the primary tumor; it's when the tumor metastasizes—or spreads the cancer to other areas of the body.
Cancer
Sep 11, 2012 |
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Do deficits in brain cannabinoids contribute to eating disorders?
A new report in Biological Psychiatry suggests that deficits in endocannabinoid function may contribute to anorexia nervosa and bulimia. Endocannabinoids are substances made by the brain that affect brain function and ch ...
Psychology & Psychiatry
Oct 31, 2011 |
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A silver bullet to beat cancer?
The internet is awash with stories of how silver can be used to treat cancer. Now, lab tests have shown that it is as effective as the leading chemotherapy drug - and may have fewer side-effects.
Cancer
Feb 02, 2012 |
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Engineered antibody demonstrated safety, efficacy in wide range of advanced tumors
(Medical Xpress)—The engineered antibody MPDL3280A, which targets a protein called programmed death-ligand 1 (PD-L1), was safe and effective for several cancers, according to phase I study results presented at the AACR ...
Cancer
Apr 10, 2013 |
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High levels of TRAIL protein in breast milk might contribute to anticancer activity
The benefits of breast milk are well known, but why breastfeeding protects against various forms of cancer remains a mystery. A new study in the Journal of Human Lactation found high levels of cancer-fighting TNF-related apopto ...
Health
Apr 23, 2012 |
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Why cells stick: Phenomenon extends longevity of bonds between cells
Research carried out by scientists at the Georgia Institute of Technology and The University of Manchester has revealed new insights into how cells stick to each other and to other bodily structures, an essential function ...
Medical research
Feb 14, 2013 |
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Immune cells, 'macrophages' become activated by body temperature
Macrophages playing an important role in the immune system eat and fight against pathogens and foreign substances in the very beginning of infection. In this condition, macrophages produce reactive oxygen species for sterilization. ...
Immunology
Apr 09, 2012 |
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Possible new pathway can overcome glioblastoma resistance
Glioblastoma, a lethal brain cancer, is one of the most resistant to available therapies and patients typically live approximately 15 months.
Cancer
Jan 24, 2012 |
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Jump-starting cheaper cancer vaccines
Dendritic cells (DCs)—workhorses of the immune system—derived from human embryonic stem cells (hESCs) may provide an economical way of generating off-the-shelf therapeutic vaccines against cancers, according ...
Immunology
Sep 26, 2012 |
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Ligand
In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from covalent to ionic. Furthermore, the metal-ligand bond order can range from one to three. Ligands are viewed as Lewis bases, although rare cases are known involving Lewis acidic "ligands."
Metal and metalloids are bound to ligands in virtually all circumstances, although gaseous "naked" metal ions can be generated in high vacuum. Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry, homogeneous catalysis, and environmental chemistry.
Ligands are classified in many ways: their charge, their size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity). The size of a ligand is indicated by its cone angle.
For more information about Ligand, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
