A study led by researchers at the University of Chicago and Indiana University has determined that a protein called elF5A is necessary for driving inflammation in macrophage cells in obesity. Blocking DHPS, the enzyme that ...
Sep 7, 2021
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78
The triggers and causes of a severe scarring disease of the lungs—idiopathic pulmonary fibrosis, or IPF—remain unclear.
Mar 18, 2021
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102
When we tear a muscle " stem cells within it repair the problem. We can see this occurring not only in severe muscle wasting diseases such as muscular dystrophy and in war veterans who survive catastrophic limb injuries, ...
Feb 10, 2021
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Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. ...
Jan 13, 2021
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48
In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet in Sweden describe how immune cells called macrophages develop in the lungs and which ...
Jan 4, 2021
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128
The immune response to infections is a delicate balance. We need just enough action to clear away the offending bacteria or viruses, but not so much that our own bodies suffer collateral damage.
Oct 15, 2020
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211
Macrophages are white blood cells that, depending on the signals they get from the immune system, become specialized in either increasing or decreasing inflammation. When macrophages are programmed to be pro-inflammatory, ...
Aug 24, 2020
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137
Macrophages are immune cells that patrol the body looking for potential threats like viruses, bacteria, and cancer cells, and engulf and destroy them. However, cancerous tumors have a nasty trick up their sleeves: they secrete ...
Apr 29, 2020
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143
In recent years it has been increasingly appreciated that immune cells within the tumor microenvironment contribute to tumor progression and, importantly, to the tumor's response to therapy. To better understand the specific ...
Aug 26, 2019
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41
Macrophages are white blood cells that accumulate in tumors, where they aid cancer progression. Now scientists have identified a surface protein found only on the macrophages residing in tumors, exposing a target for precise ...
Aug 2, 2019
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