A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism. The findings, ...
Mar 8, 2013
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Researchers at Uppsala University have cloned a T-cell receptor that binds to an antigen associated with prostate cancer and breast cancer. T cells that have been genetically equipped with this T-cell receptor have the ability ...
Sep 13, 2012
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Malignant melanoma is a type of skin cancer that originates from melanocytes or nevi, causing about 80% of skin cancer-related deaths. While some cases have shown significant response to existing molecular targeted therapies, ...
Sep 5, 2023
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(Medical Xpress)—Scientists at the Cancer Research UK Manchester Institute, The University of Manchester and King's College London have discovered a new way that melanoma skin cancer cells can invade healthy tissue and ...
Jun 26, 2014
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(Medical Xpress)—A pair of studies by a team of University of Notre Dame researchers led by Crislyn D'Souza-Schorey, professor of biological sciences, sheds light on a biological process that is activated across a vast ...
Jul 12, 2013
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Melanoma cells become drug resistant by using surrounding healthy cells to provide a 'safe haven' from treatment, according to new research published in Cancer Cell today.
Apr 13, 2015
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A newly developed antibody targeting a signalling pathway that is frequently active in solid tumours has shown encouraging signs of efficacy in its first trial in humans, researchers will report at the 24th EORTC-NCI-AACR ...
Nov 6, 2012
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It is undisputed that radon is a risk factor for developing lung cancer. New research by the Swiss Tropical and Public Health Institute (Swiss TPH) in the context of the Swiss National Cohort study now shows that the naturally ...
Jun 16, 2017
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University of Hawai'i Cancer Center researchers have discovered germline BAP1 mutations are associated with a novel cancer syndrome characterized by malignant mesothelioma, uveal melanoma, cutaneous melanoma and atypical ...
Sep 6, 2012
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Melanoma is particularly dangerous because it can form metastases in vital organs such as the lungs, liver or brain. UV radiation is considered to be the most significant triggering factor. An interdisciplinary team of researchers ...
Feb 26, 2014
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