News tagged with metabolic diseases

Related topics: type 2 diabetes

Discovery could lead to new cancer treatment

A team of scientists from the University of Colorado School of Medicine has reported the breakthrough discovery of a process to expand production of stem cells used to treat cancer patients. These findings could have implications ...

Aug 29, 2014
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Explaining 'healthy' obesity

Up to one-quarter of individuals currently labeled as obese are actually metabolically healthy and do not have a high risk of developing type 2 diabetes. Though obesity is a major risk factor for diabetes, ...

Jul 03, 2014
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Big data analytics can predict risk of metabolic syndrome

Research published today in the American Journal of Managed Care demonstrates that analysis of patient records using state-of-the-art data analytics can predict future risk of metabolic syndrome. More than a third of the ...

Jun 27, 2014
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Study results may help people with type 2 diabetes

Findings from a new study (i) published in Nutrition, Metabolism & Cardiovascular Diseases show that the fatty acids in nuts have the potential to help reduce the risk of coronary heart disease (CHD) in peo ...

Jun 24, 2014
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Inborn error of metabolism

Inborn errors of metabolism comprise a large class of genetic diseases involving disorders of metabolism. The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances (substrates) into others (products). In most of the disorders, problems arise due to accumulation of substances which are toxic or interfere with normal function, or to the effects of reduced ability to synthesize essential compounds. Inborn errors of metabolism are now often referred to as congenital metabolic diseases or inherited metabolic diseases, and these terms are considered synonymous.

The term inborn error of metabolism was coined by a British physician, Archibald Garrod (1857-1936), in the early 20th century (1908). He is known for work that prefigured the "one gene, one enzyme" hypothesis, based on his studies on the nature and inheritance of alkaptonuria. His seminal text, Inborn Errors of Metabolism was published in 1923.

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