Past neuroscience research consistently found a link between deviations from the "normal" iron metabolism, also known as iron dysregulation, and different neurodegenerative diseases, including Parkinson's disease (PD) and ...
A study led by the Department of Cardiovascular Medicine, Center for Circadian Metabolism and Cardiovascular Disease, Southwest Hospital, Army Medical University, China, looked into how meal timing regulates exercise capacity ...
Adults with obesity and nonalcoholic fatty liver disease did not see additional reductions in intrahepatic triglyceride while on a time-restricted eating regimen compared to subjects on a daily calorie-restriction diet. This ...
Researchers at the National University in Singapore and colleagues in the US and China undertook a two-decade metabolic analysis of Global Burden of Disease (GBD) reports. They have published their findings in the journal ...
Chronic kidney disease (CKD) is a feature of inherited metabolic disorders such as methylmalonic acidimia (MMA), which can cause impaired growth and low metabolic activity to delay the diagnosis and management of renal disease. ...
A small chemical change—shifting the position of two hydrogen atoms—makes the difference between mice that are healthy and mice with insulin resistance and fatty liver, major risk factors for diabetes and heart disease. ...
Jul 4, 2019
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Emulsifiers, which are added to most processed foods to aid texture and extend shelf life, can alter the gut microbiota composition and localization to induce intestinal inflammation that promotes the development of inflammatory ...
Feb 25, 2015
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(Medical Xpress)—To survive in cold environments, mammals burn fat to produce heat. The breakdown of fat helps prevent obesity and related metabolic diseases, such as diabetes. Bruce Spiegelman and his colleagues at Harvard ...
For more than 20 years, doctors have been using cells from blood that remains in the placenta and umbilical cord after childbirth to treat a variety of illnesses, from cancer and immune disorders to blood and metabolic diseases.
Jul 16, 2012
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Excess nutrients, such as fat and sugar, don't just pack on the pounds but can push some cells in the body over the brink. Unable to tolerate this "toxic" environment, these cells commit suicide.
Jul 5, 2011
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Inborn errors of metabolism comprise a large class of genetic diseases involving disorders of metabolism. The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances (substrates) into others (products). In most of the disorders, problems arise due to accumulation of substances which are toxic or interfere with normal function, or to the effects of reduced ability to synthesize essential compounds. Inborn errors of metabolism are now often referred to as congenital metabolic diseases or inherited metabolic diseases, and these terms are considered synonymous.
The term inborn error of metabolism was coined by a British physician, Archibald Garrod (1857-1936), in the early 20th century (1908). He is known for work that prefigured the "one gene, one enzyme" hypothesis, based on his studies on the nature and inheritance of alkaptonuria. His seminal text, Inborn Errors of Metabolism was published in 1923.
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